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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Taf1cem1(IMPC)Bay
endonuclease-mediated mutation 1, Baylor College of Medicine
MGI:7426012
Summary 3 genotypes


Genotype
MGI:7720086
hm1
Allelic
Composition		 Taf1cem1(IMPC)Bay/Taf1cem1(IMPC)Bay
Genetic
Background		 C57BL/6NJ-Taf1cem1(IMPC)Bay/Mmmh
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Taf1cem1(IMPC)Bay mutation (1 available); any Taf1c mutation (41 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype

Taf1cem1(IMPC)Bay/Taf1cem1(IMPC)Bay mice exhibit embryonic lethality, with embryos recovered at E3.5 as blastocysts but not at E7.5. Blastocysts fail to hatch from the zona pellucida and die after 3 days in culture, never forming outgrowths.

mortality/aging
embryonic lethality before implantation, complete penetrance ( J:279207 )
• blastocysts are present at E3.5 (15% versus expected 25%, n=33); no homozygous embryos or excess resorption sites are observed at E7.5

embryo
failure of blastocyst to hatch from the zona pellucida ( J:279207 )
• in vitro, blastocysts fail to hatch from the zona pellucida after 3 days in culture

reproductive system
failure of embryo implantation ( J:279207 )
• in vitro outgrowth assays show that blastocysts fail to hatch and are dead after 3 days in culture, never forming outgrowths




Genotype
MGI:7472271
hm2
Allelic
Composition		 Taf1cem1(IMPC)Bay/Taf1cem1(IMPC)Bay
Genetic
Background		 C57BL/6N-Taf1cem1(IMPC)Bay/BayMmucd
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Taf1cem1(IMPC)Bay mutation (1 available); any Taf1c mutation (41 available)
Data Sources
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging




Genotype
MGI:7551233
ht3
Allelic
Composition		 Taf1cem1(IMPC)Bay/Taf1c+
Genetic
Background		 C57BL/6N-Taf1cem1(IMPC)Bay/BayMmucd
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Taf1cem1(IMPC)Bay mutation (1 available); any Taf1c mutation (41 available)
Data Sources
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
behavior/neurological
hyperactivity ( J:211773 )
IMPC - BCM




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
12/10/2024
MGI 6.24 		The Jackson Laboratory