Phenotypes associated with this allele

• Allele Symbol: Vcan^em2(IMPC)Mbp
• Allele Name: endonuclease-mediated mutation 2, Mouse Biology Program, UC Davis
• Allele ID: MGI:7426078
• Summary: 2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Vcan^em2(IMPC)Mbp/Vcan^em2(IMPC)Mbp	C57BL/6NCrl-Vcan^em2(IMPC)Mbp/Mmucd	MGI:7596573
ht2	Vcan^em2(IMPC)Mbp/Vcan^+	C57BL/6NCrl-Vcan^em2(IMPC)Mbp/Mmucd	MGI:7596572

Genotype
MGI:7596573

hm1

• Allelic Composition: Vcan^em2(IMPC)Mbp/Vcan^em2(IMPC)Mbp
• Genetic Background: C57BL/6NCrl-Vcan^em2(IMPC)Mbp/Mmucd

Data Sources

IMPC Data for Vcan

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

cardiovascular system

abnormal vitelline vasculature morphology ( J:211773 )

IMPC - UCD

abnormal heart morphology ( J:211773 )

IMPC - UCD

abnormal heart looping ( J:211773 )

IMPC - UCD

craniofacial

abnormal pharyngeal arch morphology ( J:211773 )

♀

IMPC - UCD

embryo

abnormal vitelline vasculature morphology ( J:211773 )

IMPC - UCD

abnormal pharyngeal arch morphology ( J:211773 )

♀

IMPC - UCD

abnormal embryo turning ( J:211773 )

IMPC - UCD

embryonic growth retardation ( J:211773 )

IMPC - UCD

abnormal neural tube morphology ( J:211773 )

♂

IMPC - UCD

abnormal somite shape ( J:211773 )

IMPC - UCD

abnormal visceral yolk sac morphology ( J:211773 )

IMPC - UCD

growth/size/body

embryonic growth retardation ( J:211773 )

IMPC - UCD

mortality/aging

prenatal lethality prior to heart atrial septation ( J:211773 )

IMPC - UCD

preweaning lethality, complete penetrance ( J:211773 )

IMPC - UCD

nervous system

abnormal neural tube morphology ( J:211773 )

♂

IMPC - UCD

vision/eye

abnormal optic vesicle formation ( J:211773 )

♀

IMPC - UCD

Genotype
MGI:7596572

ht2

• Allelic Composition: Vcan^em2(IMPC)Mbp/Vcan⁺
• Genetic Background: C57BL/6NCrl-Vcan^em2(IMPC)Mbp/Mmucd

Data Sources

IMPC Data for Vcan

cardiovascular system

abnormal heart morphology ( J:211773 )

IMPC - UCD

eye hemorrhage ( J:211773 )

♀

IMPC - UCD

embryo

abnormal placenta morphology ( J:211773 )

IMPC - UCD

growth/size/body

enlarged spleen ( J:211773 )

♀

IMPC - UCD

hematopoietic system

abnormal spleen morphology ( J:211773 )

♀

IMPC - UCD

enlarged spleen ( J:211773 )

♀

IMPC - UCD

immune system

abnormal spleen morphology ( J:211773 )

♀

IMPC - UCD

enlarged spleen ( J:211773 )

♀

IMPC - UCD

vision/eye

eye hemorrhage ( J:211773 )

♀

IMPC - UCD

abnormal eye morphology ( J:211773 )

♀

IMPC - UCD

persistence of hyaloid vascular system ( J:211773 )

IMPC - UCD

microphthalmia ( J:211773 )

IMPC - UCD

abnormal retina morphology ( J:211773 )

IMPC - UCD