Phenotypes associated with this allele

• Allele Symbol: Del(7Mrgpra2a-Mrgpra2b)1Xzd
• Allele Name: deletion, Chr 7, Xinzhong Dong 1
• Allele ID: MGI:7427349
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Del(7Mrgpra2a-Mrgpra2b)1Xzd/Del(7Mrgpra2a-Mrgpra2b)1Xzd	C57BL/6J-Del(7Mrgpra2a-Mrgpra2b)1Xzd	MGI:7427374

Genotype
MGI:7427374

hm1

• Allelic Composition: Del(7Mrgpra2a-Mrgpra2b)1Xzd/Del(7Mrgpra2a-Mrgpra2b)1Xzd
• Genetic Background: C57BL/6J-Del(7Mrgpra2a-Mrgpra2b)1Xzd

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

immune system

abnormal neutrophil physiology ( J:332494 )

• unlike wild-type cells, neutrophils fail to respond to human BD3 or mouse BD14 stimuli

decreased interleukin-1 beta secretion ( J:332494 )

• in neutrophils stimulated with LTA and human BD3 or mouse BD14

increased susceptibility to bacterial infection ( J:332494 )

• despite injection of human BD3, mice exposed to S. aureus exhibit higher bacterial load in a greater area compared with control mice

• however, adoptive transfer of wild-type neutrophils restores normal response to S. aureus infection

integument

abnormal skin morphology ( J:332494 )

• mice exhibit dysbiosis, reduced microbiome diversity, and enrichment of Staphylococcus in the skin compared with control mice

hematopoietic system

abnormal neutrophil physiology ( J:332494 )

• unlike wild-type cells, neutrophils fail to respond to human BD3 or mouse BD14 stimuli