Phenotypes associated with this allele

• Allele Symbol: Del(8Defa1-Def)2Xzd
• Allele Name: deletion, Chr 8, Xinzhong Dong 2
• Allele ID: MGI:7427351
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
cn1	Del(8Defa1-Def)2Xzd/Del(8Defa1-Def)2Xzd Tg(KRT14-cre)1Amc/0	involves: C57BL/6J * CBA	MGI:7427375

Genotype
MGI:7427375

cn1

• Allelic Composition: Del(8Defa1-Def)2Xzd/Del(8Defa1-Def)2Xzd; Tg(KRT14-cre)1Amc/0
• Genetic Background: involves: C57BL/6J * CBA

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

immune system

increased susceptibility to bacterial infection ( J:332494 )

• mice exposed to S. aureus exhibit higher bacterial load in a greater area compared with control mice

• however, injection of human BD3 restores normal response to S. aureus infection

integument

abnormal skin morphology ( J:332494 )

• mice exhibit dysbiosis, reduced microbiome diversity, and enrichment of Staphylococcus in the skin compared with control mice