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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Prss54tm1Zgwg
targeted mutation 1, Zhugang Wang
MGI:7427434
Summary 1 genotype
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Prss54tm1Zgwg/Prss54tm1Zgwg involves: C57BL/6J * C57BL/6N MGI:7427437


Genotype
MGI:7427437
hm1
Allelic
Composition		 Prss54tm1Zgwg/Prss54tm1Zgwg
Genetic
Background		 involves: C57BL/6J * C57BL/6N
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Prss54tm1Zgwg mutation (0 available); any Prss54 mutation (20 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
reproductive system
reproductive system phenotype ( J:332475 )
N
• female mice exhibit normal fertility
abnormal acrosome morphology ( J:332475 )
• apical hooks are not smooth and sharp as in wild-type sperm
• irregular sac-like unlike in wild-type sperm
• however, transgene re-expression rescues acrosome morphology
reduced male fertility ( J:332475 )
• however, transgene re-expression rescues fertility

cellular
abnormal acrosome morphology ( J:332475 )
• apical hooks are not smooth and sharp as in wild-type sperm
• irregular sac-like unlike in wild-type sperm
• however, transgene re-expression rescues acrosome morphology




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
12/10/2024
MGI 6.24 		The Jackson Laboratory