Phenotypes associated with this allele

• Allele Symbol: Ormdl2^em1Pdra
• Allele Name: endonuclease-mediated mutation 1, Petr Draber
• Allele ID: MGI:7427586
• Summary: 4 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Ormdl2^em1Pdra/Ormdl2^em1Pdra	C57BL/6-Ormdl2^em1Pdra	MGI:7427595
cx2	Ormdl1^em1Pdra/Ormdl1^em1Pdra Ormdl2^em1Pdra/Ormdl2^em1Pdra	C57BL/6-Ormdl1^em1Pdra Ormdl2^em1Pdra	MGI:7657413
cx3	Ormdl1^em1Pdra/Ormdl1^em1Pdra Ormdl2^em1Pdra/Ormdl2^em1Pdra Ormdl3^em1Pdra/Ormdl3^em1Pdra	C57BL/6-Ormdl1^em1Pdra Ormdl2^em1Pdra Ormdl3^em1Pdra	MGI:7657417
cx4	Ormdl2^em1Pdra/Ormdl2^em1Pdra Ormdl3^em1Pdra/Ormdl3^em1Pdra	C57BL/6-Ormdl2^em1Pdra Ormdl3^em1Pdra	MGI:7427599

Genotype
MGI:7427595

hm1

• Allelic Composition: Ormdl2^em1Pdra/Ormdl2^em1Pdra
• Genetic Background: C57BL/6-Ormdl2^em1Pdra

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

immune system

immune system phenotype ( J:328837 , J:349248 )

N • bone marrow-derived mast cells exhibit normal proliferation, degranulation, and ceramide and sphingosine levels (J:328837)

N • mice exhibit normal response to passive cutaneous or systemic anaphylaxis (J:328837)

N • high-affinity IgE receptor-mediated degranulation and calcium response of bone marrow-derived mast cells following activation with antigen is similar to the response seen in antigen-activated wild-type mast cells and total ceramide levels in bone marrow-derived mast cells are unchanged (J:349248)

Genotype
MGI:7657413

cx2

• Allelic Composition: Ormdl1^em1Pdra/Ormdl1^em1Pdra; Ormdl2^em1Pdra/Ormdl2^em1Pdra
• Genetic Background: C57BL/6-Ormdl1^em1Pdra Ormdl2^em1Pdra

immune system

immune system phenotype ( J:349248 )

N • high-affinity IgE receptor-mediated degranulation and calcium response of bone marrow-derived mast cells following activation with antigen is similar to the response seen in antigen-activated wild-type mast cells and total ceramide levels in bone marrow-derived mast cells are unchanged

N • mast cells do not vary phenotypically from wild-type mast cells

Genotype
MGI:7657417

cx3

• Allelic Composition: Ormdl1^em1Pdra/Ormdl1^em1Pdra; Ormdl2^em1Pdra/Ormdl2^em1Pdra; Ormdl3^em1Pdra/Ormdl3^em1Pdra
• Genetic Background: C57BL/6-Ormdl1^em1Pdra Ormdl2^em1Pdra Ormdl3^em1Pdra

mortality/aging

prenatal lethality, complete penetrance ( J:349248 )

• no homozygous mice are obtained

Genotype
MGI:7427599

cx4

• Allelic Composition: Ormdl2^em1Pdra/Ormdl2^em1Pdra; Ormdl3^em1Pdra/Ormdl3^em1Pdra
• Genetic Background: C57BL/6-Ormdl2^em1Pdra Ormdl3^em1Pdra

immune system

abnormal mast cell physiology ( J:328837 )

• bone marrow-derived mast cells exhibit increased proliferation compared with cells from wild-type mice

increased mast cell degranulation ( J:328837 )

abnormal type I hypersensitivity reaction ( J:328837 )

• mice exhibit increased passive cutaneous anaphylaxis but faster recovery from passive systemic anaphylaxis compared with wild-type mice

• however, mice exhibit normal passive cutaneous anaphylaxis

increased interleukin-4 secretion ( J:328837 )

• in antigen-activated bone marrow-derived mast cells

increased interleukin-6 secretion ( J:328837 )

• in antigen-activated bone marrow-derived mast cells

increased tumor necrosis factor secretion ( J:328837 )

• in antigen-activated bone marrow-derived mast cells

homeostasis/metabolism

increased ceramide level ( J:328837 )

• in bone marrow-derived mast cells

increased sphingosine level ( J:328837 )

• in bone marrow-derived mast cells

hematopoietic system

abnormal mast cell physiology ( J:328837 )

• bone marrow-derived mast cells exhibit increased proliferation compared with cells from wild-type mice

increased mast cell degranulation ( J:328837 )

cellular

increased mast cell degranulation ( J:328837 )