About   Help   FAQ
Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Ormdl3em1Pdra
endonuclease-mediated mutation 1, Petr Draber
MGI:7427587
Summary 4 genotypes


Genotype
MGI:7427597
hm1
Allelic
Composition		 Ormdl3em1Pdra/Ormdl3em1Pdra
Genetic
Background		 C57BL/6-Ormdl3em1Pdra
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ormdl3em1Pdra mutation (0 available); any Ormdl3 mutation (10 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
abnormal mast cell physiology ( J:328837 )
• bone marrow-derived mast cells exhibit increased proliferation compared with cells from wild-type mice
abnormal type I hypersensitivity reaction ( J:328837 )
• mice exhibit faster recovery from passive systemic anaphylaxis compared with wild-type mice
• however, mice exhibit normal passive cutaneous anaphylaxis

homeostasis/metabolism
increased ceramide level ( J:328837 , J:349248 )
• in bone marrow-derived mast cells (J:328837)
• concentration of total ceramide levels are increased in bone marrow-derived mast cells (J:349248)
increased sphingosine level ( J:328837 , J:349248 )
• in bone marrow-derived mast cells (J:328837)
• concentration of sphingosine (C18:1) is increased in bone marrow-derived mast cells (J:349248)

hematopoietic system
abnormal mast cell physiology ( J:328837 )
• bone marrow-derived mast cells exhibit increased proliferation compared with cells from wild-type mice

cellular




Genotype
MGI:7657417
cx2
Allelic
Composition		 Ormdl1em1Pdra/Ormdl1em1Pdra
Ormdl2em1Pdra/Ormdl2em1Pdra
Ormdl3em1Pdra/Ormdl3em1Pdra
Genetic
Background		 C57BL/6-Ormdl1em1Pdra Ormdl2em1Pdra Ormdl3em1Pdra
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ormdl1em1Pdra mutation (0 available); any Ormdl1 mutation (15 available)
Ormdl2em1Pdra mutation (0 available); any Ormdl2 mutation (9 available)
Ormdl3em1Pdra mutation (0 available); any Ormdl3 mutation (10 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging
prenatal lethality, complete penetrance ( J:349248 )
• no homozygous mice are obtained




Genotype
MGI:7657415
cx3
Allelic
Composition		 Ormdl1em1Pdra/Ormdl1em1Pdra
Ormdl3em1Pdra/Ormdl3em1Pdra
Genetic
Background		 C57BL/6-Ormdl1em1Pdra Ormdl3em1Pdra
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ormdl1em1Pdra mutation (0 available); any Ormdl1 mutation (15 available)
Ormdl3em1Pdra mutation (0 available); any Ormdl3 mutation (10 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
growth/size/body
decreased body size ( J:349248 )
decreased body weight ( J:349248 )

hematopoietic system
abnormal mast cell physiology ( J:349248 )
• high-affinity IgE receptor-mediated calcium response of bone marrow-derived mast cells following activation with antigen is increased compared to the response seen in antigen-activated wild-type mast cells, without a corresponding increase in degranulation

homeostasis/metabolism
increased ceramide level ( J:349248 )
• concentrations of sphinganine (C18:0) and sphingosine (C18:1) and total ceramide levels, as well as individual long- and very long-chain ceramide species, are increased in bone marrow-derived mast cells
increased sphingosine level ( J:349248 )
• concentration of sphingosine (C18:1) is increased in bone marrow-derived mast cells

immune system
abnormal mast cell physiology ( J:349248 )
• high-affinity IgE receptor-mediated calcium response of bone marrow-derived mast cells following activation with antigen is increased compared to the response seen in antigen-activated wild-type mast cells, without a corresponding increase in degranulation




Genotype
MGI:7427599
cx4
Allelic
Composition		 Ormdl2em1Pdra/Ormdl2em1Pdra
Ormdl3em1Pdra/Ormdl3em1Pdra
Genetic
Background		 C57BL/6-Ormdl2em1Pdra Ormdl3em1Pdra
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ormdl2em1Pdra mutation (0 available); any Ormdl2 mutation (9 available)
Ormdl3em1Pdra mutation (0 available); any Ormdl3 mutation (10 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
abnormal mast cell physiology ( J:328837 )
• bone marrow-derived mast cells exhibit increased proliferation compared with cells from wild-type mice
abnormal type I hypersensitivity reaction ( J:328837 )
• mice exhibit increased passive cutaneous anaphylaxis but faster recovery from passive systemic anaphylaxis compared with wild-type mice
• however, mice exhibit normal passive cutaneous anaphylaxis
increased interleukin-4 secretion ( J:328837 )
• in antigen-activated bone marrow-derived mast cells
increased interleukin-6 secretion ( J:328837 )
• in antigen-activated bone marrow-derived mast cells
increased tumor necrosis factor secretion ( J:328837 )
• in antigen-activated bone marrow-derived mast cells

homeostasis/metabolism
increased ceramide level ( J:328837 )
• in bone marrow-derived mast cells
increased sphingosine level ( J:328837 )
• in bone marrow-derived mast cells

hematopoietic system
abnormal mast cell physiology ( J:328837 )
• bone marrow-derived mast cells exhibit increased proliferation compared with cells from wild-type mice

cellular




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
Send questions and comments to User Support. 		last database update
11/19/2024
MGI 6.24 		The Jackson Laboratory