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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Ccl27alem1Nax
endonuclease-mediated mutation 1, Na Xiong
MGI:7427639
Summary 2 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
cx1
 		Ccl27aem1Nax/Ccl27aem1Nax
Ccl27alem1Nax/Ccl27alem1Nax
Ccl27bem1Nax/Ccl27bem1Nax 		involves: C57BL/6 MGI:7643507
cx2
 		Ccl27aem1Nax/Ccl27aem1Nax
Ccl27alem1Nax/Ccl27alem1Nax
Ccl27bem1Nax/Ccl27bem1Nax
Ccr10tm1.1Nax/Ccr10+ 		involves: C57BL/6 MGI:7643522


Genotype
MGI:7643507
cx1
Allelic
Composition		 Ccl27aem1Nax/Ccl27aem1Nax
Ccl27alem1Nax/Ccl27alem1Nax
Ccl27bem1Nax/Ccl27bem1Nax
Genetic
Background		 involves: C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ccl27aem1Nax mutation (0 available); any Ccl27a mutation (13 available)
Ccl27alem1Nax mutation (0 available); any Ccl27al mutation (4 available)
Ccl27bem1Nax mutation (0 available); any Ccl27b mutation (0 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
impaired leukocyte migration ( J:330550 )
• mice exhibit severely impaired migration of CCR10+ lymphocytes into the skin; in vivo migration assays show significantly lower total numbers and percentages of donor cells that express CCR10(EGFP)+ in the skin, but not in the spleen, of recipient mice
increased interleukin-17 secretion ( J:330550 )
• mice show overactivation of IL-17-producing skin T cells in response to topical imiquimod (IMQ) stimulation
increased susceptibility to chemically induced skin inflammation ( J:330550 )
• in response to topical IMQ stimulation, IMQ-treated ears show more severe psoriasis-like skin inflammation with increased epidermal thickness and significantly higher percentages of IL-17A+ total, gamma-delta, CD8+ and CD4+ T cells than similarly treated control ears

integument
increased susceptibility to chemically induced skin inflammation ( J:330550 )
• in response to topical IMQ stimulation, IMQ-treated ears show more severe psoriasis-like skin inflammation with increased epidermal thickness and significantly higher percentages of IL-17A+ total, gamma-delta, CD8+ and CD4+ T cells than similarly treated control ears

cellular
impaired leukocyte migration ( J:330550 )
• mice exhibit severely impaired migration of CCR10+ lymphocytes into the skin; in vivo migration assays show significantly lower total numbers and percentages of donor cells that express CCR10(EGFP)+ in the skin, but not in the spleen, of recipient mice

hematopoietic system
impaired leukocyte migration ( J:330550 )
• mice exhibit severely impaired migration of CCR10+ lymphocytes into the skin; in vivo migration assays show significantly lower total numbers and percentages of donor cells that express CCR10(EGFP)+ in the skin, but not in the spleen, of recipient mice




Genotype
MGI:7643522
cx2
Allelic
Composition		 Ccl27aem1Nax/Ccl27aem1Nax
Ccl27alem1Nax/Ccl27alem1Nax
Ccl27bem1Nax/Ccl27bem1Nax
Ccr10tm1.1Nax/Ccr10+
Genetic
Background		 involves: C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ccl27aem1Nax mutation (0 available); any Ccl27a mutation (13 available)
Ccl27alem1Nax mutation (0 available); any Ccl27al mutation (4 available)
Ccl27bem1Nax mutation (0 available); any Ccl27b mutation (0 available)
Ccr10tm1.1Nax mutation (0 available); any Ccr10 mutation (13 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
impaired leukocyte migration ( J:330550 )
• mice show impaired establishment and dysregulated localization of CCR10+ lymphocytes in the skin
• numbers of alpha-beta T cells and percentages of CCR10(EGFP)+ Treg cells, alpha-beta T cells, gamma-delta T cells, and innate lymphoid cells (ILCs) are significantly lower in the skin at 2 weeks of age
• similarly, numbers of alpha-beta T cells and percentages of CCR10(EGFP)+ Treg cells, CD8+ T cells, CD4+ T cells, gamma-delta T cells, and ILCs, are significantly lower in the skin of adult mice
• numbers of CCR10(EGFP)+ CD4+ T cells and CD8+ T cells are significantly reduced in adult skin
• adult mice show a lower percentage of CCR10(EGFP)+ ILCs and T cells localized close to/on the skin hair follicles but a higher percentage localized below hair follicles
• percentages of CCR10(EGFP)+ CD4+ T cells, CD8+ T cells, and ILCs are significantly increased in the blood and spleen of adult mice, suggesting that CCR10+ lymphocytes do not effectively migrate into the skin and instead continue to circulate in the blood and accumulate in the spleen
• percentages of CCR10(EGFP)+ CD4+ and CD8+ alpha-beta T cells are significantly increased in the lungs and uteri of adult mice, whereas frequencies of CCR10(EGFP)+ ILCs and gamma-delta T cells are mildly increased or unchanged in these mucosal tissues
• however, total numbers of skin gamma-delta T cells and ILCs as well as the percentage of CCR10(EGFP)+ gamma-delta T cells in the blood and spleen are not significantly altered
increased interleukin-10 secretion ( J:330550 )
• adult mice show a small (<5%) increase in the percentage of IL-10-expressing skin CD4+ T cells relative to controls
• however, no significant differences are noted in the production of IL-17A or IFN-gamma by total or CCR10(EGFP)+ skin ILCs, CD8 +, CD4+, and gamma-delta T cells
uterus inflammation ( J:330550 )
• some mice show visible signs of spontaneous uterus inflammation

reproductive system
abnormal uterus physiology ( J:330550 )
• uteri show a significant increase in the percentages of CCR10(EGFP)+ CD4+ and CD8+ alpha-beta T cells along with an increase in the absolute number of CD45+ immune cells, indicating immune dysregulation in uterine tissue
uterus inflammation ( J:330550 )
• some mice show visible signs of spontaneous uterus inflammation

cellular
impaired leukocyte migration ( J:330550 )
• mice show impaired establishment and dysregulated localization of CCR10+ lymphocytes in the skin
• numbers of alpha-beta T cells and percentages of CCR10(EGFP)+ Treg cells, alpha-beta T cells, gamma-delta T cells, and innate lymphoid cells (ILCs) are significantly lower in the skin at 2 weeks of age
• similarly, numbers of alpha-beta T cells and percentages of CCR10(EGFP)+ Treg cells, CD8+ T cells, CD4+ T cells, gamma-delta T cells, and ILCs, are significantly lower in the skin of adult mice
• numbers of CCR10(EGFP)+ CD4+ T cells and CD8+ T cells are significantly reduced in adult skin
• adult mice show a lower percentage of CCR10(EGFP)+ ILCs and T cells localized close to/on the skin hair follicles but a higher percentage localized below hair follicles
• percentages of CCR10(EGFP)+ CD4+ T cells, CD8+ T cells, and ILCs are significantly increased in the blood and spleen of adult mice, suggesting that CCR10+ lymphocytes do not effectively migrate into the skin and instead continue to circulate in the blood and accumulate in the spleen
• percentages of CCR10(EGFP)+ CD4+ and CD8+ alpha-beta T cells are significantly increased in the lungs and uteri of adult mice, whereas frequencies of CCR10(EGFP)+ ILCs and gamma-delta T cells are mildly increased or unchanged in these mucosal tissues
• however, total numbers of skin gamma-delta T cells and ILCs as well as the percentage of CCR10(EGFP)+ gamma-delta T cells in the blood and spleen are not significantly altered

hematopoietic system
impaired leukocyte migration ( J:330550 )
• mice show impaired establishment and dysregulated localization of CCR10+ lymphocytes in the skin
• numbers of alpha-beta T cells and percentages of CCR10(EGFP)+ Treg cells, alpha-beta T cells, gamma-delta T cells, and innate lymphoid cells (ILCs) are significantly lower in the skin at 2 weeks of age
• similarly, numbers of alpha-beta T cells and percentages of CCR10(EGFP)+ Treg cells, CD8+ T cells, CD4+ T cells, gamma-delta T cells, and ILCs, are significantly lower in the skin of adult mice
• numbers of CCR10(EGFP)+ CD4+ T cells and CD8+ T cells are significantly reduced in adult skin
• adult mice show a lower percentage of CCR10(EGFP)+ ILCs and T cells localized close to/on the skin hair follicles but a higher percentage localized below hair follicles
• percentages of CCR10(EGFP)+ CD4+ T cells, CD8+ T cells, and ILCs are significantly increased in the blood and spleen of adult mice, suggesting that CCR10+ lymphocytes do not effectively migrate into the skin and instead continue to circulate in the blood and accumulate in the spleen
• percentages of CCR10(EGFP)+ CD4+ and CD8+ alpha-beta T cells are significantly increased in the lungs and uteri of adult mice, whereas frequencies of CCR10(EGFP)+ ILCs and gamma-delta T cells are mildly increased or unchanged in these mucosal tissues
• however, total numbers of skin gamma-delta T cells and ILCs as well as the percentage of CCR10(EGFP)+ gamma-delta T cells in the blood and spleen are not significantly altered




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Send questions and comments to User Support. 		last database update
11/12/2024
MGI 6.24 		The Jackson Laboratory