About   Help   FAQ
Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Defb19em1Cya
endonuclease-mediated mutation 1, Cyagen Biosciences
MGI:7427681
Summary 1 genotype
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Defb19em1Cya/Defb19em1Cya C57BL/6-Defb19em1Cya MGI:7427684


Genotype
MGI:7427684
hm1
Allelic
Composition		 Defb19em1Cya/Defb19em1Cya
Genetic
Background		 C57BL/6-Defb19em1Cya
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Defb19em1Cya mutation (0 available); any Defb19 mutation (10 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
reproductive system
reduced female fertility ( J:332576 )
• female mice sired a lower number of litters compared with wild-type mice
abnormal fertilization ( J:332576 )
• reduced ability of oocytes to attract sperm with reduced sperm count in the oviduct and reduced forward sperm migration induced by cumulus cell conditioned medium

Mouse Models of Human Disease
 DO ID OMIM ID(s) Ref(s)
female reproductive system disease DOID:229 J:332576




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
Send questions and comments to User Support. 		last database update
12/10/2024
MGI 6.24 		The Jackson Laboratory