Phenotypes associated with this allele

• Allele Symbol: Adamtsl3^em1Apte
• Allele Name: endonuclease-mediated mutation 1, Suneel Apte
• Allele ID: MGI:7427743
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Adamtsl3^em1Apte/Adamtsl3^em1Apte	C57BL/6J-Adamtsl3^em1Apte	MGI:7427793

Genotype
MGI:7427793

hm1

• Allelic Composition: Adamtsl3^em1Apte/Adamtsl3^em1Apte
• Genetic Background: C57BL/6J-Adamtsl3^em1Apte

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

cardiovascular system

increased heart weight ( J:332622 )

• hearts weigh 9-13% more than in wild-type mice

increased response of heart to induced stress ( J:332622 )

• mice develop exacerbated cardiac dilatation and contractile dysfunction with faster progression to decompensation and higher mortality post aortic banding induced pressure overload, with mice not regaining weight loss at 6 weeks post aortic banding, showing greater absolute left ventricle mass and weight, increased left ventricular inner diameter and left ventricular end-diastolic volume, reduced fractional shortening and left ventricle ejection fraction, and reduced peak mitral inflow velocity and mitral valve inflow deceleration

• left atrial diameter and lung weights are increased at 6 weeks post-aortic banding, suggesting circulatory congestion

• however, mice exhibit normal cardiac dimensions and function at 8-12 weeks of age at baseline

growth/size/body

increased heart weight ( J:332622 )

• hearts weigh 9-13% more than in wild-type mice

homeostasis/metabolism

increased response of heart to induced stress ( J:332622 )

• mice develop exacerbated cardiac dilatation and contractile dysfunction with faster progression to decompensation and higher mortality post aortic banding induced pressure overload, with mice not regaining weight loss at 6 weeks post aortic banding, showing greater absolute left ventricle mass and weight, increased left ventricular inner diameter and left ventricular end-diastolic volume, reduced fractional shortening and left ventricle ejection fraction, and reduced peak mitral inflow velocity and mitral valve inflow deceleration

• left atrial diameter and lung weights are increased at 6 weeks post-aortic banding, suggesting circulatory congestion

• however, mice exhibit normal cardiac dimensions and function at 8-12 weeks of age at baseline

limbs/digits/tail

long tibia ( J:332622 )

• tibia bones are 2-3% longer than in wild-type mice

mortality/aging

mortality/aging ( J:332622 )

N • mice survive into maturity without apparent early lethality

skeleton

long tibia ( J:332622 )

• tibia bones are 2-3% longer than in wild-type mice