Analysis Tools
cellular
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• active Trp53-positive cells (a marker of apoptosis) are detected at E7.5
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embryo
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• active Trp53-positive cells (a marker of apoptosis) are detected at E7.5
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• embryos fail to initiate gastrulation; no Brachyury (T)-positive cells are present at E7.5
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• embryos show a severe developmental delay at E7.5
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• embryos are much smaller than controls at E7.5
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• a small egg cylinder is observed at E7.5
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• no Brachyury (T)-positive cells are present at E7.5
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• extraembryonic tissues are poorly organized at E7.5
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growth/size/body
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• embryos show a severe developmental delay at E7.5
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• embryos are much smaller than controls at E7.5
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mortality/aging
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IMPC - JAX
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• homozygous embryos are present in expected Mendelian ratios at E7.5; no homozygous embryos are recovered at E9.5
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