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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID
Ccdc93em1(IMPC)J
endonuclease-mediated mutation 1, Jackson
MGI:7427746
Summary 2 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
Ccdc93em1(IMPC)J/Ccdc93em1(IMPC)J C57BL/6NJ-Ccdc93em1(IMPC)J/Mmjax MGI:7551064
ht2
Ccdc93em1(IMPC)J/Ccdc93+ C57BL/6NJ-Ccdc93em1(IMPC)J/Mmjax MGI:7628934


Genotype
MGI:7551064
hm1
Allelic
Composition
Ccdc93em1(IMPC)J/Ccdc93em1(IMPC)J
Genetic
Background
C57BL/6NJ-Ccdc93em1(IMPC)J/Mmjax
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ccdc93em1(IMPC)J mutation (2 available); any Ccdc93 mutation (54 available)
Data Sources
phenotype observed in females
phenotype observed in males
N normal phenotype

Ccdc93em1(IMPC)J/Ccdc93em1(IMPC)J mice exhibit embryonic lethality between E7.5 and E9.5, growth retardation, poorly organized extraembryonic tissues, failure of primitive streak formation and gastrulation, and increased cell death.

cellular
• active Trp53-positive cells (a marker of apoptosis) are detected at E7.5

embryo
• active Trp53-positive cells (a marker of apoptosis) are detected at E7.5
• embryos fail to initiate gastrulation; no Brachyury (T)-positive cells are present at E7.5
• embryos show a severe developmental delay at E7.5
• embryos are much smaller than controls at E7.5
• a small egg cylinder is observed at E7.5
• no Brachyury (T)-positive cells are present at E7.5
• extraembryonic tissues are poorly organized at E7.5

growth/size/body
• embryos show a severe developmental delay at E7.5
• embryos are much smaller than controls at E7.5

mortality/aging
• homozygous embryos are present in expected Mendelian ratios at E7.5; no homozygous embryos are recovered at E9.5




Genotype
MGI:7628934
ht2
Allelic
Composition
Ccdc93em1(IMPC)J/Ccdc93+
Genetic
Background
C57BL/6NJ-Ccdc93em1(IMPC)J/Mmjax
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ccdc93em1(IMPC)J mutation (2 available); any Ccdc93 mutation (54 available)
Data Sources
phenotype observed in females
phenotype observed in males
N normal phenotype
adipose tissue

cardiovascular system

growth/size/body

skeleton





Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
11/12/2024
MGI 6.24
The Jackson Laboratory