All Phenotypes Ccdc93<em1(IMPC)J> MGI Mouse

Phenotypes associated with this allele

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Ccdc93^em1(IMPC)J/Ccdc93^em1(IMPC)J	C57BL/6NJ-Ccdc93^em1(IMPC)J/Mmjax	MGI:7551064
ht2	Ccdc93^em1(IMPC)J/Ccdc93⁺	C57BL/6NJ-Ccdc93^em1(IMPC)J/Mmjax	MGI:7628934

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

Ccdc93^em1(IMPC)J/Ccdc93^em1(IMPC)J mice exhibit embryonic lethality between E7.5 and E9.5, growth retardation, poorly organized extraembryonic tissues, failure of primitive streak formation and gastrulation, and increased cell death.

cellular

increased embryonic tissue cell apoptosis ( J:279207 )

• active Trp53-positive cells (a marker of apoptosis) are detected at E7.5

embryo

increased embryonic tissue cell apoptosis ( J:279207 )

• active Trp53-positive cells (a marker of apoptosis) are detected at E7.5

failure to gastrulate ( J:279207 )

• embryos fail to initiate gastrulation; no Brachyury (T)-positive cells are present at E7.5

embryonic growth retardation ( J:279207 )

• embryos show a severe developmental delay at E7.5

decreased embryo size ( J:279207 )

• embryos are much smaller than controls at E7.5

abnormal egg cylinder morphology ( J:279207 )

• a small egg cylinder is observed at E7.5

failure of primitive streak formation ( J:279207 )

• no Brachyury (T)-positive cells are present at E7.5

disorganized extraembryonic tissue ( J:279207 )

• extraembryonic tissues are poorly organized at E7.5

growth/size/body

embryonic growth retardation ( J:279207 )

• embryos show a severe developmental delay at E7.5

decreased embryo size ( J:279207 )

• embryos are much smaller than controls at E7.5

mortality/aging

preweaning lethality, complete penetrance ( J:211773 )

IMPC - JAX

embryonic lethality between implantation and placentation, complete penetrance ( J:279207 )

• homozygous embryos are present in expected Mendelian ratios at E7.5; no homozygous embryos are recovered at E9.5

Allelic Composition	Ccdc93^em1(IMPC)J/Ccdc93⁺
Genetic Background	C57BL/6NJ-Ccdc93^em1(IMPC)J/Mmjax

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ccdc93^em1(IMPC)J mutation (2 available); any Ccdc93 mutation (54 available)

Data Sources

IMPC Data for Ccdc93

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

adipose tissue

increased total body fat amount ( J:211773 )

IMPC - JAX

cardiovascular system

decreased heart weight ( J:211773 )

IMPC - JAX

growth/size/body

decreased lean body mass ( J:211773 )

IMPC - JAX

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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