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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Ano9em1Uoh
endonuclease-mediated mutation 1, Uhtaek Oh
MGI:7428505
Summary 2 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
cn1
 		Ano9em1Uoh/Ano9em1Uoh
Omptm4(cre)Mom/Omp+ 		involves: 129P2/OlaHsd * C57BL/6 MGI:7581989
cn2
 		Ano9em1Uoh/Ano9em1.1Uoh
Tg(CMV-cre)1Cgn/0 		involves: BALB/cJ * C57BL/6 MGI:7581987


Genotype
MGI:7581989
cn1
Allelic
Composition		 Ano9em1Uoh/Ano9em1Uoh
Omptm4(cre)Mom/Omp+
Genetic
Background		 involves: 129P2/OlaHsd * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ano9em1Uoh mutation (0 available); any Ano9 mutation (41 available)
Omptm4(cre)Mom mutation (2 available); any Omp mutation (27 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
behavior/neurological
abnormal olfactory behavior ( J:344977 )
• fail to show a preference for peanut butter odor
• fail to show an aversive reaction to 2-methyl butyric acid
• following reward training, fail to show preference for the trained scent, carvone




Genotype
MGI:7581987
cn2
Allelic
Composition		 Ano9em1Uoh/Ano9em1.1Uoh
Tg(CMV-cre)1Cgn/0
Genetic
Background		 involves: BALB/cJ * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ano9em1.1Uoh mutation (0 available); any Ano9 mutation (41 available)
Ano9em1Uoh mutation (0 available); any Ano9 mutation (41 available)
Tg(CMV-cre)1Cgn mutation (6 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
taste/olfaction
abnormal olfactory sensory neuron physiology ( J:344977 )
• freshly isolated olfactory sensory neurons elicit cAMP-evoked currents with markedly reduced amplitudes
impaired olfaction ( J:344977 )
• reduced electro-olfactogram responses to odorant containing air puffs
• olfactory bulb responses (calcium signals) are significantly reduced compared to controls

behavior/neurological
abnormal olfactory behavior ( J:344977 )
• fail to show a preference for peanut butter odor
• fail to show an aversive reaction to 2-methyl butyric acid
• following reward training, fail to show preference for the trained scent, carvone

nervous system
abnormal olfactory sensory neuron physiology ( J:344977 )
• freshly isolated olfactory sensory neurons elicit cAMP-evoked currents with markedly reduced amplitudes

respiratory system
abnormal olfactory sensory neuron physiology ( J:344977 )
• freshly isolated olfactory sensory neurons elicit cAMP-evoked currents with markedly reduced amplitudes




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
11/12/2024
MGI 6.24 		The Jackson Laboratory