Phenotypes associated with this allele

• Allele Symbol: Rr344^em1Jfer
• Allele Name: endonuclease-mediated mutation 1, Jorge Ferrer
• Allele ID: MGI:7428576
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Rr344^em1Jfer/Rr344^em1Jfer	B6.Cg-Rr344^em1Jfer	MGI:7428596

Genotype
MGI:7428596

hm1

• Allelic Composition: Rr344^em1Jfer/Rr344^em1Jfer
• Genetic Background: B6.Cg-Rr344^em1Jfer

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

digestive/alimentary system

dilated pancreatic duct ( J:328047 )

• from E12.5 onward

growth/size/body

decreased body weight ( J:328047 )

• at 6 to 11 weeks of age

homeostasis/metabolism

decreased glucagon secretion ( J:328047 )

decreased insulin secretion ( J:328047 )

hyperglycemia ( J:328047 )

• severely soon after birth

decreased circulating insulin level ( J:328047 )

• in fed mice

endocrine/exocrine glands

dilated pancreatic duct ( J:328047 )

• from E12.5 onward

decreased pancreatic alpha cell mass ( J:328047 )

decreased pancreatic beta cell mass ( J:328047 )

abnormal branching involved in pancreas development ( J:328047 )

abnormal pancreatic bud formation ( J:328047 )

• moderately reduced pancreatic buds at E10.5-E11.5 with severely stunted subsequent growth due to reduced proliferation

pancreas hypoplasia ( J:328047 )

decreased glucagon secretion ( J:328047 )

decreased insulin secretion ( J:328047 )

abnormal pancreatic somatostatin secretion ( J:328047 )

• decreased