Analysis Tools
homeostasis/metabolism
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• bone marrow derived macrophages (BMDMs) treated with ferric ammonium citrate (FAC) to induce iron overload, followed by fresh iron-free medium to drive iron export, take up iron during FAC treatment similarly as controls but have increased iron export
• 3-week-old mice fed a high-iron diet for 6 weeks, followed by a low-iron diet for 5 weeks display a decrease in hepatic iron and more pronounced decrease in nonheme iron in the spleen
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• slight, but not significant, decrease of spleen iron at 2 months of age, which reaches significance at 5 months of age
• splenic macrophages show reduced iron levels at 5 months of age
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• 2-month-old mice injected with iron dextran to cause iron overload show less iron retained in the spleen and splenic macrophages resulting in higher serum iron and transferrin saturation levels
• 10-week-old mice fed a low-iron diet (LID) injected with hepcidin show higher levels of serum iron levels
• LPS-induced hypoferremia is less severe than in controls
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hematopoietic system
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• slight, but not significant, decrease of spleen iron at 2 months of age, which reaches significance at 5 months of age
• splenic macrophages show reduced iron levels at 5 months of age
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immune system
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• slight, but not significant, decrease of spleen iron at 2 months of age, which reaches significance at 5 months of age
• splenic macrophages show reduced iron levels at 5 months of age
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