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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID
Tti1em1(IMPC)J
endonuclease-mediated mutation 1, Jackson
MGI:7428768
Summary 2 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
Tti1em1(IMPC)J/Tti1em1(IMPC)J C57BL/6NJ-Tti1em1(IMPC)J/Mmjax MGI:7629138
ht2
Tti1em1(IMPC)J/Tti1+ C57BL/6NJ-Tti1em1(IMPC)J/Mmjax MGI:7629137


Genotype
MGI:7629138
hm1
Allelic
Composition
Tti1em1(IMPC)J/Tti1em1(IMPC)J
Genetic
Background
C57BL/6NJ-Tti1em1(IMPC)J/Mmjax
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tti1em1(IMPC)J mutation (2 available); any Tti1 mutation (49 available)
Data Sources
phenotype observed in females
phenotype observed in males
N normal phenotype

Tti1em1(IMPC)J/Tti1em1(IMPC)J mice exhibit embryonic lethality, with embryos recovered at E3.5 as blastocysts but not at E7.5. Blastocysts hatch from the zona pellucida and form typical outgrowths.

mortality/aging
• although blastocysts are recovered at expected Mendelian ratios at E3.5, no homozygous embryos can be recovered at E7.5
• however, excess resorption sites suggest that embryos elicit a decidual response in vivo
• in vitro, blastocysts hatch from the zona pellucida and form typical outgrowth colonies after 3 days in culture




Genotype
MGI:7629137
ht2
Allelic
Composition
Tti1em1(IMPC)J/Tti1+
Genetic
Background
C57BL/6NJ-Tti1em1(IMPC)J/Mmjax
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tti1em1(IMPC)J mutation (2 available); any Tti1 mutation (49 available)
Data Sources
phenotype observed in females
phenotype observed in males
N normal phenotype
hematopoietic system

homeostasis/metabolism

immune system





Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
10/29/2024
MGI 6.24
The Jackson Laboratory