Phenotypes associated with this allele

• Allele Symbol: Tti1^em1(IMPC)J
• Allele Name: endonuclease-mediated mutation 1, Jackson
• Allele ID: MGI:7428768
• Summary: 2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Tti1^em1(IMPC)J/Tti1^em1(IMPC)J	C57BL/6NJ-Tti1^em1(IMPC)J/Mmjax	MGI:7629138
ht2	Tti1^em1(IMPC)J/Tti1^+	C57BL/6NJ-Tti1^em1(IMPC)J/Mmjax	MGI:7629137

Genotype
MGI:7629138

hm1

• Allelic Composition: Tti1^em1(IMPC)J/Tti1^em1(IMPC)J
• Genetic Background: C57BL/6NJ-Tti1^em1(IMPC)J/Mmjax

Data Sources

IMPC Data for Tti1

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

Tti1^em1(IMPC)J/Tti1^em1(IMPC)J mice exhibit embryonic lethality, with embryos recovered at E3.5 as blastocysts but not at E7.5. Blastocysts hatch from the zona pellucida and form typical outgrowths.

mortality/aging

preweaning lethality, complete penetrance ( J:211773 )

IMPC - JAX

embryonic lethality between implantation and somite formation, complete penetrance ( J:279207 )

• although blastocysts are recovered at expected Mendelian ratios at E3.5, no homozygous embryos can be recovered at E7.5

• however, excess resorption sites suggest that embryos elicit a decidual response in vivo

• in vitro, blastocysts hatch from the zona pellucida and form typical outgrowth colonies after 3 days in culture

Genotype
MGI:7629137

ht2

• Allelic Composition: Tti1^em1(IMPC)J/Tti1⁺
• Genetic Background: C57BL/6NJ-Tti1^em1(IMPC)J/Mmjax

Data Sources

IMPC Data for Tti1

hearing/vestibular/ear

abnormal auditory brainstem response ( J:211773 )

IMPC - JAX

hematopoietic system

decreased leukocyte cell number ( J:211773 )

IMPC - JAX

homeostasis/metabolism

decreased circulating HDL cholesterol level ( J:211773 )

♂

IMPC - JAX

immune system

decreased leukocyte cell number ( J:211773 )

IMPC - JAX