All Phenotypes Tg(tetO/Prnp-SNCA*A53T)4360Tmd MGI Mouse

About Help FAQ

Phenotypes associated with this allele

Allele Symbol
Allele Name
Allele ID

Tg(tetO/Prnp-SNCA*A53T)4360Tmd
transgene insertion 4360, Ted M Dawson
MGI:7428915

Summary

3 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
cn1	Tg(tetO/Prnp-SNCA*A53T)4360Tmd/0	involves: C3H * C57BL/6	MGI:7764515
cn2	Abl1^tm1Ajk/Abl1^tm1Ajk Tg(Nes-cre)1Kag/0 Tg(tetO/Prnp-SNCA*A53T)4360Tmd/0	involves: 129S4/SvJae * C3H * C57BL/6	MGI:7764516
cx3	Tg(tetO/Prnp-SNCA*A53T)4360Tmd/0 Zfp746^tm1.1Tmd/Zfp746^tm1.1Tmd	involves: 129S4/SvJae * C3H * C57BL/6	MGI:7764517

Allelic Composition	Tg(tetO/Prnp-SNCA*A53T)4360Tmd/0
Genetic Background	involves: C3H * C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tg(tetO/Prnp-SNCA*A53T)4360Tmd mutation (1 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

homeostasis/metabolism

decreased dopamine level ( J:327648 )

• mice injected with an adenovirus expressing tTA into the ventral midbrain and then treated with doxycycline show a reduction in dopamine and its metabolites

nervous system

astrocytosis ( J:327648 )

• mice injected with an adenovirus expressing tTA into the ventral midbrain show an increase in GFAP immunoreactivity

loss of dopaminergic neurons ( J:327648 )

• mice injected with an adenovirus expressing tTA into the ventral midbrain and then treated with doxycycline show a robust loss of dopamine neurons

• mice injected with an adenovirus expressing tTA into the ventral midbrain show a reduction in striatal dopamine fiber density

• mice injected with an adenovirus expressing tTA into the ventral midbrain show an increase in amphetamine-induced rotational behavior, indicating loss of dopamine neurons

Allelic Composition	Abl1^tm1Ajk/Abl1^tm1Ajk Tg(Nes-cre)1Kag/0 Tg(tetO/Prnp-SNCA*A53T)4360Tmd/0
Genetic Background	involves: 129S4/SvJae * C3H * C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Abl1^tm1Ajk mutation (1 available); any Abl1 mutation (93 available)
Tg(Nes-cre)1Kag mutation (0 available)
Tg(tetO/Prnp-SNCA*A53T)4360Tmd mutation (1 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

nervous system

nervous system phenotype ( J:327648 )

• mice injected with an adenovirus expressing tTA into the ventral midbrain and then treated with doxycycline show rescue of the nigral degeneration of dopamine neurons and loss of dopamine seen in single Tg(tetO/Prnp-SNCA*A53T)4360Tmd/0 mice

• mice injected with an adenovirus expressing tTA into the ventral midbrain show prevention of the amphetamine-induced rotation, indicating that the dopamine neurons are functionally spared

Allelic Composition	Tg(tetO/Prnp-SNCA*A53T)4360Tmd/0 Zfp746^tm1.1Tmd/Zfp746^tm1.1Tmd
Genetic Background	involves: 129S4/SvJae * C3H * C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tg(tetO/Prnp-SNCA*A53T)4360Tmd mutation (1 available)
Zfp746^tm1.1Tmd mutation (0 available); any Zfp746 mutation (22 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

nervous system

nervous system phenotype ( J:327648 )

• mice injected with an adenovirus expressing tTA into the ventral midbrain show rescue of the dopamine neuron degeneration, loss of dopamine, and the loss of striatal dopamine fiber density, the prevention of amphetamine-induced rotation, and rescue of GFAP immunoreactivity seen in single Tg(tetO/Prnp-SNCA*A53T)4360Tmd/0 mice

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 11/12/2024 MGI 6.24