Phenotypes associated with this allele

• Allele Symbol: Klhl24^em2Xtan
• Allele Name: endonuclease-mediated mutation 2, Xu Tan
• Allele ID: MGI:7428975
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
ht1	Klhl24^em2Xtan/Klhl24^+	C57BL/6-Klhl24^em2Xtan	MGI:7432811

Genotype
MGI:7432811

ht1

• Allelic Composition: Klhl24^em2Xtan/Klhl24⁺
• Genetic Background: C57BL/6-Klhl24^em2Xtan

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

growth/size/body

decreased body size ( J:327299 )

• at 20 weeks of age

decreased body weight ( J:327299 )

• at 20 weeks of age

integument

integument phenotype ( J:327299 )

N • mice show no obvious signs of skin fragility

premature hair loss ( J:327299 )

• at 20 weeks of age, mice exhibit more pronounced age-related hair loss than wild-type controls

homeostasis/metabolism

abnormal protein level ( J:327299 )

• mice exhibit a significant reduction of keratin 14 (KRT14) protein levels in skin extracts and skin sections