About   Help   FAQ
Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Zmynd8em1Lwb
endonuclease-mediated mutation 1, Weibo Luo
MGI:7431277
Summary 2 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
cn1
 		Zmynd8em1Lwb/Zmynd8em1Lwb
Tg(MMTV-PyVT)634Mul/0
Tg(KRT14-cre)1Amc/0 		involves: C57BL/6N * CBA * FVB MGI:7432306
cn2
 		Zmynd8em1Lwb/Zmynd8em1Lwb
Tg(MMTV-cre)4Mam/0
Tg(MMTV-PyVT)634Mul/0 		involves: C57BL/6N * FVB MGI:7432304


Genotype
MGI:7432306
cn1
Allelic
Composition		 Zmynd8em1Lwb/Zmynd8em1Lwb
Tg(MMTV-PyVT)634Mul/0
Tg(KRT14-cre)1Amc/0
Genetic
Background		 involves: C57BL/6N * CBA * FVB
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tg(KRT14-cre)1Amc mutation (2 available)
Tg(MMTV-PyVT)634Mul mutation (2 available)
Zmynd8em1Lwb mutation (0 available); any Zmynd8 mutation (504 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
endocrine/exocrine glands
decreased mammary gland tumor incidence ( J:326848 )
• strongly reduced mammary tumor number and weight with no metastasis to the lungs unlike in control mice

integument
decreased mammary gland tumor incidence ( J:326848 )
• strongly reduced mammary tumor number and weight with no metastasis to the lungs unlike in control mice

neoplasm
decreased mammary gland tumor incidence ( J:326848 )
• strongly reduced mammary tumor number and weight with no metastasis to the lungs unlike in control mice




Genotype
MGI:7432304
cn2
Allelic
Composition		 Zmynd8em1Lwb/Zmynd8em1Lwb
Tg(MMTV-cre)4Mam/0
Tg(MMTV-PyVT)634Mul/0
Genetic
Background		 involves: C57BL/6N * FVB
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tg(MMTV-cre)4Mam mutation (1 available)
Tg(MMTV-PyVT)634Mul mutation (2 available)
Zmynd8em1Lwb mutation (0 available); any Zmynd8 mutation (504 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
neoplasm
decreased mammary gland tumor incidence ( J:326848 )
• reduced mammary tumor number and weight with no metastasis to the lungs unlike in control mice

integument
decreased mammary gland tumor incidence ( J:326848 )
• reduced mammary tumor number and weight with no metastasis to the lungs unlike in control mice

endocrine/exocrine glands
decreased mammary gland tumor incidence ( J:326848 )
• reduced mammary tumor number and weight with no metastasis to the lungs unlike in control mice




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
Send questions and comments to User Support. 		last database update
12/10/2024
MGI 6.24 		The Jackson Laboratory