Phenotypes associated with this allele

• Allele Symbol: Trex1^{em1(IMPC)Ccpcz}
• Allele Name: endonuclease-mediated mutation 1, Institute of Molecular Genetics
• Allele ID: MGI:7431384
• Summary: 2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Trex1^em1(IMPC)Ccpcz/Trex1^em1(IMPC)Ccpcz	C57BL/6NCrl-Trex1^em1(IMPC)Ccpcz/Ccpcz	MGI:7768443
ht2	Trex1^em1(IMPC)Ccpcz/Trex1^+	C57BL/6NCrl-Trex1^em1(IMPC)Ccpcz/Ccpcz	MGI:7768442

Genotype
MGI:7768443

hm1

• Allelic Composition: Trex1^{em1(IMPC)Ccpcz}/Trex1^{em1(IMPC)Ccpcz}
• Genetic Background: C57BL/6NCrl-Trex1^{em1(IMPC)Ccpcz}/Ccpcz

Data Sources

IMPC Data for Trex1

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

adipose tissue

decreased total body fat amount ( J:211773 )

IMPC - CCP-IMG

cardiovascular system

abnormal heart morphology ( J:211773 )

IMPC - CCP-IMG

enlarged heart ( J:211773 )

IMPC - CCP-IMG

increased heart weight ( J:211773 )

♀

IMPC - CCP-IMG

craniofacial

abnormal tooth color ( J:211773 )

♂

IMPC - CCP-IMG

endocrine/exocrine glands

abnormal thymus morphology ( J:211773 )

♀

IMPC - CCP-IMG

enlarged thymus ( J:211773 )

♀

IMPC - CCP-IMG

growth/size/body

enlarged heart ( J:211773 )

IMPC - CCP-IMG

increased heart weight ( J:211773 )

♀

IMPC - CCP-IMG

abnormal tooth color ( J:211773 )

♂

IMPC - CCP-IMG

increased lean body mass ( J:211773 )

♀

IMPC - CCP-IMG

increased kidney weight ( J:211773 )

IMPC - CCP-IMG

enlarged liver ( J:211773 )

♀

IMPC - CCP-IMG

enlarged spleen ( J:211773 )

IMPC - CCP-IMG

increased spleen weight ( J:211773 )

IMPC - CCP-IMG

hematopoietic system

abnormal thymus morphology ( J:211773 )

♀

IMPC - CCP-IMG

enlarged thymus ( J:211773 )

♀

IMPC - CCP-IMG

increased red blood cell distribution width ( J:211773 )

IMPC - CCP-IMG

increased neutrophil cell number ( J:211773 )

IMPC - CCP-IMG

thrombocytopenia ( J:211773 )

IMPC - CCP-IMG

increased mean platelet volume ( J:211773 )

IMPC - CCP-IMG

increased effector memory T-helper cell number ( J:211773 )

♀

IMPC - CCP-IMG

decreased lymphocyte cell number ( J:211773 )

IMPC - CCP-IMG

decreased NK cell number ( J:211773 )

♀

IMPC - CCP-IMG

increased monocyte cell number ( J:211773 )

IMPC - CCP-IMG

abnormal spleen morphology ( J:211773 )

IMPC - CCP-IMG

enlarged spleen ( J:211773 )

IMPC - CCP-IMG

increased spleen weight ( J:211773 )

IMPC - CCP-IMG

homeostasis/metabolism

improved glucose tolerance ( J:211773 )

IMPC - CCP-IMG

immune system

abnormal thymus morphology ( J:211773 )

♀

IMPC - CCP-IMG

enlarged thymus ( J:211773 )

♀

IMPC - CCP-IMG

increased neutrophil cell number ( J:211773 )

IMPC - CCP-IMG

increased effector memory T-helper cell number ( J:211773 )

♀

IMPC - CCP-IMG

decreased lymphocyte cell number ( J:211773 )

IMPC - CCP-IMG

decreased NK cell number ( J:211773 )

♀

IMPC - CCP-IMG

increased monocyte cell number ( J:211773 )

IMPC - CCP-IMG

abnormal spleen morphology ( J:211773 )

IMPC - CCP-IMG

enlarged spleen ( J:211773 )

IMPC - CCP-IMG

increased spleen weight ( J:211773 )

IMPC - CCP-IMG

integument

abnormal skin morphology ( J:211773 )

♀

IMPC - CCP-IMG

limbs/digits/tail

short tibia ( J:211773 )

♀

IMPC - CCP-IMG

liver/biliary system

abnormal liver morphology ( J:211773 )

IMPC - CCP-IMG

enlarged liver ( J:211773 )

♀

IMPC - CCP-IMG

renal/urinary system

increased kidney weight ( J:211773 )

IMPC - CCP-IMG

skeleton

abnormal tooth color ( J:211773 )

♂

IMPC - CCP-IMG

short tibia ( J:211773 )

♀

IMPC - CCP-IMG

abnormal spine curvature ( J:211773 )

IMPC - CCP-IMG

kyphosis ( J:211773 )

♀

IMPC - CCP-IMG

scoliosis ( J:211773 )

♀

IMPC - CCP-IMG

Genotype
MGI:7768442

ht2

• Allelic Composition: Trex1^{em1(IMPC)Ccpcz}/Trex1⁺
• Genetic Background: C57BL/6NCrl-Trex1^{em1(IMPC)Ccpcz}/Ccpcz

Data Sources

IMPC Data for Trex1

cardiovascular system

abnormal retina vasculature morphology ( J:211773 )

IMPC - CCP-IMG

abnormal heart morphology ( J:211773 )

♂

IMPC - CCP-IMG

enlarged heart ( J:211773 )

♂

IMPC - CCP-IMG

craniofacial

abnormal cranium morphology ( J:211773 )

♂

IMPC - CCP-IMG

endocrine/exocrine glands

abnormal seminal vesicle morphology ( J:211773 )

♂

IMPC - CCP-IMG

enlarged seminal vesicle ( J:211773 )

♂

IMPC - CCP-IMG

abnormal testis morphology ( J:211773 )

♂

IMPC - CCP-IMG

enlarged testis ( J:211773 )

♂

IMPC - CCP-IMG

growth/size/body

enlarged heart ( J:211773 )

♂

IMPC - CCP-IMG

enlarged kidney ( J:211773 )

♂

IMPC - CCP-IMG

enlarged spleen ( J:211773 )

♂

IMPC - CCP-IMG

hematopoietic system

abnormal spleen morphology ( J:211773 )

IMPC - CCP-IMG

enlarged spleen ( J:211773 )

♂

IMPC - CCP-IMG

immune system

abnormal spleen morphology ( J:211773 )

IMPC - CCP-IMG

enlarged spleen ( J:211773 )

♂

IMPC - CCP-IMG

integument

abnormal skin morphology ( J:211773 )

♀

IMPC - CCP-IMG

renal/urinary system

abnormal kidney morphology ( J:211773 )

♂

IMPC - CCP-IMG

enlarged kidney ( J:211773 )

♂

IMPC - CCP-IMG

reproductive system

abnormal seminal vesicle morphology ( J:211773 )

♂

IMPC - CCP-IMG

enlarged seminal vesicle ( J:211773 )

♂

IMPC - CCP-IMG

abnormal testis morphology ( J:211773 )

♂

IMPC - CCP-IMG

enlarged testis ( J:211773 )

♂

IMPC - CCP-IMG

abnormal epididymis morphology ( J:211773 )

♂

IMPC - CCP-IMG

enlarged epididymis ( J:211773 )

♂

IMPC - CCP-IMG

skeleton

abnormal cranium morphology ( J:211773 )

♂

IMPC - CCP-IMG

abnormal bone structure ( J:211773 )

♀

IMPC - CCP-IMG

vision/eye

abnormal retina vasculature morphology ( J:211773 )

IMPC - CCP-IMG

abnormal lens morphology ( J:211773 )

IMPC - CCP-IMG