Phenotypes associated with this allele

• Allele Symbol: Adissp^{tm1c(EUCOMM)Hmgu}
• Allele Name: targeted mutation 1c, Helmholtz Zentrum Muenchen GmbH
• Allele ID: MGI:7432545
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
cn1	Adissp^tm1c(EUCOMM)Hmgu/Adissp^tm1c(EUCOMM)Hmgu Tg(Adipoq-cre)1Evdr/0	involves: C57BL/6J * C57BL/6N * FVB/NJ	MGI:7432563

Genotype
MGI:7432563

cn1

• Allelic Composition: Adissp^{tm1c(EUCOMM)Hmgu}/Adissp^{tm1c(EUCOMM)Hmgu}; Tg(Adipoq-cre)1Evdr/0
• Genetic Background: involves: C57BL/6J * C57BL/6N * FVB/NJ

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

adipose tissue

abnormal fat cell morphology ( J:332979 )

• mice housed at 30 degrees Celsius and fed a normal chow diet for 2 months show differences in inguinal white adipose tissue (WAT) and brown adipose tissue (BAT) adipocyte morphology

abnormal white adipose tissue morphology ( J:332979 )

• intracellular cAMP content is decreased in inguinal WAT depot in mice housed at 30 degrees Celsius and fed a normal chow diet for 2 months

increased white fat cell size ( J:332979 )

• mice fed a high-fat diet show larger adipocytes

increased white adipose tissue mass ( J:332979 )

• mice housed at 30 degrees Celsius and fed a normal chow diet for 2 months show an increase in WAT mass

• mice contain more inguinal WAT mass after acute cold exposure than controls, indicating decreased fat burning

abnormal adipose tissue physiology ( J:332979 )

• inguinal WAT browning is compromised after cold exposure

• administration of CL-316,243, a beta3-adrenergic agonist, does not lead to inguinal WAT browning as in controls or a decrease in inguinal WAT mass loss

decreased adipocyte glucose uptake ( J:332979 )

• decrease in glucose uptake by inguinal WAT after cold exposure

abnormal beige fat cell physiology ( J:332979 )

• beige fat formation is impaired upon cold exposure

growth/size/body

increased susceptibility to diet-induced obesity ( J:332979 )

• mice show increased susceptibility to high-fat diet-induced obesity, with mice gaining more weight despite consuming similar amount of food as controls; body weight increase is due to fat mass and not lean mass

• however, mice have normal body weight on normal chow diet at room temperature

homeostasis/metabolism

increased susceptibility to diet-induced obesity ( J:332979 )

• mice show increased susceptibility to high-fat diet-induced obesity, with mice gaining more weight despite consuming similar amount of food as controls; body weight increase is due to fat mass and not lean mass

• however, mice have normal body weight on normal chow diet at room temperature

impaired adaptive thermogenesis ( J:332979 )

• body temperature is lower than in controls upon cold exposure

increased circulating glucose level ( J:332979 )

• both steady-state and fasting glucose levels are higher in mice fed a high-fat diet for 18 and 19 weeks

increased fasting circulating glucose level ( J:332979 )

• fasting glucose levels are higher in mice fed a high-fat diet for 18 and 19 weeks

impaired glucose tolerance ( J:332979 )

• glucose tolerance is deteriorated in mice fed a high-fat diet for 5-6 weeks and for 18 and 19 weeks

insulin resistance ( J:332979 )

• insulin sensitivity is deteriorated in mice fed a high-fat diet for 5-6 weeks and for 18 and 19 weeks

cellular

decreased adipocyte glucose uptake ( J:332979 )

• decrease in glucose uptake by inguinal WAT after cold exposure

behavior/neurological

behavior/neurological phenotype ( J:332979 )

N • mice have normal food intake as controls on normal chow diet at room temperature