Phenotypes associated with this allele

• Allele Symbol: Tg(Fabp4-Adissp)#Yxw
• Allele Name: transgene insertion, Yong-Xu Wang
• Allele ID: MGI:7432549
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
tg1	Tg(Fabp4-Adissp)#Yxw/0	involves: C57BL/6J * SJL	MGI:7432555

Genotype
MGI:7432555

tg1

• Allelic Composition: Tg(Fabp4-Adissp)#Yxw/0
• Genetic Background: involves: C57BL/6J * SJL

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

adipose tissue

abnormal fat cell morphology ( J:332979 )

• mice housed at 30 degrees Celsius and fed a normal chow diet for 1 month show differences in inguinal white adipose tissue (WAT) and brown adipose tissue (BAT) adipocyte morphology

abnormal inguinal fat pad morphology ( J:332979 )

• mice fed a chow diet show an elevated expression of thermogenic and glycolytic genes in inguinal WAT, but not in BAT or epididymal WAT

abnormal white adipose tissue morphology ( J:332979 )

• intracellular cAMP content is increased in inguinal WAT depot in mice housed at 30 degrees Celsius and fed a normal chow diet for 1 month

decreased white fat cell size ( J:332979 )

• high-fat diet fed mice show smaller inguinal WAT and epididymal WAT adipocytes

decreased white adipose tissue mass ( J:332979 )

• WAT mass is lower in mice housed at 30 degrees Celsius and fed a normal chow diet for 1 month

browned white adipose tissue morphology ( J:332979 )

• inguinal white adipose tissue browning, with numerous small, UCP1+ adipocytes

abnormal white adipose tissue physiology ( J:332979 )

• mice show a higher oxygen consumption rate in inguinal white adipose tissue

homeostasis/metabolism

decreased susceptibility to diet-induced obesity ( J:332979 )

• mice gain less body weight and fat mass on a high-fat diet, despite similar food intake as controls, indicating that mice are protected from high-fat diet-induced obesity

• however, no difference is seen in body weight on a chow diet

abnormal adaptive thermogenesis ( J:332979 )

• body temperature is increased compared to controls at cold

• however, whole-body energy expendiature is not significantly different although tends to be higher

abnormal glucose homeostasis ( J:332979 )

• mice fed a high-fat diet display better glucose homeostasis

improved glucose tolerance ( J:332979 )

• mice are more glucose tolerant indicating improved glucose homeostasis

growth/size/body

decreased susceptibility to diet-induced obesity ( J:332979 )

• mice gain less body weight and fat mass on a high-fat diet, despite similar food intake as controls, indicating that mice are protected from high-fat diet-induced obesity

• however, no difference is seen in body weight on a chow diet

behavior/neurological

behavior/neurological phenotype ( J:332979 )

N • no difference is seen in food intake on a chow diet