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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Misfaem5Kei
endonuclease-mediated mutation 5, Keiichi I Nakayama
MGI:7432755
Summary 1 genotype
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Misfaem5Kei/Misfaem5Kei C57BL/6J-Misfaem5Kei MGI:7432899


Genotype
MGI:7432899
hm1
Allelic
Composition		 Misfaem5Kei/Misfaem5Kei
Genetic
Background		 C57BL/6J-Misfaem5Kei
Find Mice Using the International Mouse Strain Resource (IMSR)
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♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
reproductive system
abnormal sperm mitochondrial sheath morphology ( J:332977 )
• impaired mitochondrial sheath structure and wavy motility
reduced male fertility ( J:332977 )
• severely reduced
decreased fertilization frequency ( J:332977 )
• complete loss of fertilization of cumulus-intact oocytes
• however, sperm fertilize oocytes lacking zona pellucida

cellular
abnormal sperm mitochondrial sheath morphology ( J:332977 )
• impaired mitochondrial sheath structure and wavy motility




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
11/19/2024
MGI 6.24 		The Jackson Laboratory