Analysis Tools
cardiovascular system
| N |
• heart size is normal during postnatal development, 2-month-old mice show normal cardiac ventricular performance by echocardiography that remains unaffected at 18 months of age, exhibit normal gross heart morphology at 2 and 18 months of age and no ultrastructural abnormalities in the heart, similar metabolic output of isolated cardiac mitochondria as in wild-type, and cardiac hypertrophy induced by transverse aortic constriction results in a similar degree of heart growth and increase in ventricular wall thickness as in wild-type mice
• although mice show no overt changes in cardiac structure/function, expression of the paralog RPL3 is upregulated and maintained in adulthood
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small heart
(
J:333030
)
|
• mice exhibit smaller hearts at 18 months of age, but not at 2 months
|
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• mice exhibit a mild but significant reduction in heart weight over time
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homeostasis/metabolism
| N |
• mice show no differences from wild-type mice in treadmill running
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muscle
| N |
• tibialis anterior skeletal muscle weights at baseline and following 10 days of denervation are similar to wild-type
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