Analysis Tools
homeostasis/metabolism
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• male mice injected with streptozotocin (STZ) to induce insulin-dependent diabetes are protected from the weight loss and muscle mass loss that is seen in wild-type mice, and show attenuated urine albumin level and albumin/creatinine ratio, and protection from glomerular hypertrophy, mesangial matrix expansion, glomerular tuft and tubulointerstitial fibrosis, glomerular basement membrane thickening, podocyte foot process effacement, mitochondrial abnormalities in glomeruli, and podocyte loss that is seen in wild-type mice at 24 hours post diabetes induction indicating protection from features of diabetic kidney disease
• however, no difference in incidence of STZ-induced diabetes is seen or in food intake, water intake or movement, in oxygen consumption or CO2 production, in respiratory exchange ratio
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renal/urinary system
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• glomerular mesangial cells are protected from high glucose-induced mitochondrial dysfunction, showing increased oxygen consumption rate at basal respiration, ATP production rate, and maximal respiration compared to wild-type cells, indicating that mitochondrial activity is maintained at higher levels
• mesangial cells show no significant decrease of mitophagy after 5 days of high glucose treatment unlike wild-type mesangial cells which show a decreased adaptive mitophagy
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