Phenotypes associated with this allele

• Allele Symbol: Tg(Id4-EGFP)LT-11B6Oat
• Allele Name: transgene insertion LT-11B6, Jon Oatley
• Allele ID: MGI:7435197
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
cx1	Pramel1^em1Liuw/Pramel1^em1Liuw Tg(Id4-EGFP)LT-11B6Oat/0	involves: C57BL/6 * FVB	MGI:7855824

Genotype
MGI:7855824

cx1

• Allelic Composition: Pramel1^em1Liuw/Pramel1^em1Liuw; Tg(Id4-EGFP)LT-11B6Oat/0
• Genetic Background: involves: C57BL/6 * FVB

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

reproductive system

abnormal spermatogonia morphology ( J:342835 )

♂ • cells that fail to home and undergo apoptosis at P3 are the progenitor cells based on expression level of the GFP reporter

abnormal seminiferous tubule morphology ( J:342835 )

♂ • Sertoli cells-only segments are seen

♂ • treatment with a retinoic acid inhibitor rescues the Sertoli cells-only phenotype and treatment with all-trans retinoic acid increases the frequency of this phenotype

abnormal seminiferous tubule epithelium morphology ( J:342835 )

♂ • average length of the seminiferous epithelial cycle is significantly (83%) longer compared to controls at P7

cellular

abnormal spermatogonia morphology ( J:342835 )

♂ • cells that fail to home and undergo apoptosis at P3 are the progenitor cells based on expression level of the GFP reporter

endocrine/exocrine glands

abnormal seminiferous tubule morphology ( J:342835 )

♂ • Sertoli cells-only segments are seen

♂ • treatment with a retinoic acid inhibitor rescues the Sertoli cells-only phenotype and treatment with all-trans retinoic acid increases the frequency of this phenotype

abnormal seminiferous tubule epithelium morphology ( J:342835 )

♂ • average length of the seminiferous epithelial cycle is significantly (83%) longer compared to controls at P7