Phenotypes associated with this allele

• Allele Symbol: Lztfl1^tm1.2Zpl
• Allele Name: targeted mutation 1.2, Zhi-Ping Liu
• Allele ID: MGI:7435274
• Summary: 2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
cn1	Lztfl1^tm1.2Zpl/Lztfl1^tm1.2Zpl Tg(Camk2a-cre)#Stl/0	involves: 129S4/SvJaeSor * BALB/c * C57BL * C57BL/6 * C57BL/6N	MGI:7435346
cn2	Lztfl1^tm1.2Zpl/Lztfl1^tm1.2Zpl Tg(Adipoq-cre)1Evdr/0	involves: 129S4/SvJaeSor * C57BL/6 * C57BL/6N * FVB/NJ	MGI:7435344

Genotype
MGI:7435346

cn1

• Allelic Composition: Lztfl1^tm1.2Zpl/Lztfl1^tm1.2Zpl; Tg(Camk2a-cre)#Stl/0
• Genetic Background: involves: 129S4/SvJaeSor * BALB/c * C57BL * C57BL/6 * C57BL/6N

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

endocrine/exocrine glands

abnormal interlobular bile duct morphology ( J:287261 )

• mice show enlarged interlobular ducts

abnormal pancreas morphology ( J:287261 )

• pancreatic hypertrophy with enlarged islets and interlobular ducts

pancreatic islet hyperplasia ( J:287261 )

• mice show enlarged islets

growth/size/body

obese ( J:287261 )

• mice develop obesity in adulthood

homeostasis/metabolism

impaired glucose tolerance ( J:287261 )

• adults show delayed clearance of oral glucose in the oral glucose tolerance test

insulin resistance ( J:287261 )

• adults show decreased insulin sensitivity in the insulin tolerance test

liver/biliary system

abnormal interlobular bile duct morphology ( J:287261 )

• mice show enlarged interlobular ducts

hepatic steatosis ( J:287261 )

• livers exhibit extensive microvesicular and macrovesicular steatosis

Genotype
MGI:7435344

cn2

• Allelic Composition: Lztfl1^tm1.2Zpl/Lztfl1^tm1.2Zpl; Tg(Adipoq-cre)1Evdr/0
• Genetic Background: involves: 129S4/SvJaeSor * C57BL/6 * C57BL/6N * FVB/NJ

normal phenotype

no abnormal phenotype detected ( J:287261 )

• mice are born normal and indistinguishable from wild-type mice and do not become obese