Phenotypes associated with this allele

• Allele Symbol: Adgrg6^em1Jlp
• Allele Name: endonuclease-mediated mutation 1, Jose Luis de la Pompa
• Allele ID: MGI:7438175
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Adgrg6^em1Jlp/Adgrg6^em1Jlp	C57BL/6-Adgrg6^em1Jlp	MGI:7442277

Genotype
MGI:7442277

hm1

• Allelic Composition: Adgrg6^em1Jlp/Adgrg6^em1Jlp
• Genetic Background: C57BL/6-Adgrg6^em1Jlp

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

mortality/aging ( J:315981 )

N • heterozygous intercrosses yield homozygous offspring in normal Mendelian ratios during embryonic development and in live births

growth/size/body

decreased body size ( J:315981 )

• at P2, mice are slightly smaller than wild-type and heterozygous littermates

limbs/digits/tail

abnormal forelimb morphology ( J:315981 )

• at P2, forelimbs are severely affected (rigid)

abnormal hindlimb morphology ( J:315981 )

• at P2, hindlimbs are severely affected (rigid)

skeleton

joint contracture ( J:315981 )

• pups exhibit stiff joint contractures in the forelimbs and hindlimbs that impede body balance and normal locomotion

nervous system

abnormal nervous system development ( J:315981 )

• abnormal peripheral nervous system (PNS) development

abnormal myelination ( J:315981 )

• abnormal PNS myelination

behavior/neurological

abnormal motor coordination/balance ( J:315981 )

abnormal locomotor behavior ( J:315981 )

cardiovascular system

cardiovascular system phenotype ( J:315981 )

N • mice exhibit normal heart morphology from E12.5 to P2