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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Adgrg6em3Jlp
endonuclease-mediated mutation 3, Jose Luis de la Pompa
MGI:7438177
Summary 6 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
cn1
 		Adgrg6em3Jlp/Adgrg6em3Jlp
Nfatc1tm1.1(cre)Bz/Nfatc1+ 		involves: 129S1/Sv * 129X1/SvJ * C57BL/6 MGI:7442262
cn2
 		Adgrg6em3Jlp/Adgrg6em3Jlp
Mesp1tm2(cre)Ysa/Mesp1+ 		involves: C57BL/6 * C57BL/6NCrlj * CBA/JNCrlj MGI:7442267
cn3
 		Adgrg6em2Jlp/Adgrg6em3Jlp
Mesp1tm2(cre)Ysa/Mesp1+ 		involves: C57BL/6 * C57BL/6NCrlj * CBA/JNCrlj MGI:7442269
cn4
 		Adgrg6em3Jlp/Adgrg6em3Jlp
Edil3Tg(Sox2-cre)1Amc/Edil3+ 		involves: C57BL/6 * CBA MGI:7442279
cn5
 		Adgrg6em3Jlp/Adgrg6em3Jlp
Tg(Tek-cre)1Ywa/0 		involves: C57BL/6 * SJL MGI:7442264
cn6
 		Adgrg6em2Jlp/Adgrg6em3Jlp
Tg(Tek-cre)1Ywa/0 		involves: C57BL/6 * SJL MGI:7442268


Genotype
MGI:7442262
cn1
Allelic
Composition		 Adgrg6em3Jlp/Adgrg6em3Jlp
Nfatc1tm1.1(cre)Bz/Nfatc1+
Genetic
Background		 involves: 129S1/Sv * 129X1/SvJ * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Adgrg6em3Jlp mutation (0 available); any Adgrg6 mutation (65 available)
Nfatc1tm1.1(cre)Bz mutation (0 available); any Nfatc1 mutation (49 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
normal phenotype
no abnormal phenotype detected ( J:315981 )
• unexpectedly, mice are viable throughout embryogenesis with no resorptions observed from E11.5 to E18.5 and no cardiac abnormalities detected at E15.5




Genotype
MGI:7442267
cn2
Allelic
Composition		 Adgrg6em3Jlp/Adgrg6em3Jlp
Mesp1tm2(cre)Ysa/Mesp1+
Genetic
Background		 involves: C57BL/6 * C57BL/6NCrlj * CBA/JNCrlj
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Adgrg6em3Jlp mutation (0 available); any Adgrg6 mutation (65 available)
Mesp1tm2(cre)Ysa mutation (3 available); any Mesp1 mutation (18 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
normal phenotype
no abnormal phenotype detected ( J:315981 )
• mice are viable from E12.5 to E18.5 and do not show any obvious heart phenotype at E15.5




Genotype
MGI:7442269
cn3
Allelic
Composition		 Adgrg6em2Jlp/Adgrg6em3Jlp
Mesp1tm2(cre)Ysa/Mesp1+
Genetic
Background		 involves: C57BL/6 * C57BL/6NCrlj * CBA/JNCrlj
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Adgrg6em2Jlp mutation (0 available); any Adgrg6 mutation (65 available)
Adgrg6em3Jlp mutation (0 available); any Adgrg6 mutation (65 available)
Mesp1tm2(cre)Ysa mutation (3 available); any Mesp1 mutation (18 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
normal phenotype
no abnormal phenotype detected ( J:315981 )
• mice exhibit no evidence of embryonic lethality; no cardiac defects are detected at E16.5




Genotype
MGI:7442279
cn4
Allelic
Composition		 Adgrg6em3Jlp/Adgrg6em3Jlp
Edil3Tg(Sox2-cre)1Amc/Edil3+
Genetic
Background		 involves: C57BL/6 * CBA
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Adgrg6em3Jlp mutation (0 available); any Adgrg6 mutation (65 available)
Edil3Tg(Sox2-cre)1Amc mutation (5 available); any Edil3 mutation (43 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging
lethality throughout fetal growth and development, incomplete penetrance ( J:315981 )
• when the cre transgene is inherited paternally, 73% of embryos are viable past E13.5 and 64% survive to birth
embryonic lethality during organogenesis, complete penetrance ( J:315981 )
• when the cre transgene is inherited maternally, embryos do not survive past E13.5

growth/size/body
decreased body size ( J:315981 )
• when the cre transgene is inherited paternally, pups exhibit a marked reduction in overall size at P1

skeleton
joint contracture ( J:315981 )
• when the cre transgene is inherited paternally, pups exhibit stiff joint contractures in the forelimbs and hindlimbs at P1

cardiovascular system
small heart ( J:315981 )
• when the cre transgene is inherited paternally, hearts are smaller but otherwise structurally normal at P1; no morphological cardiac defects are noted at E16.5




Genotype
MGI:7442264
cn5
Allelic
Composition		 Adgrg6em3Jlp/Adgrg6em3Jlp
Tg(Tek-cre)1Ywa/0
Genetic
Background		 involves: C57BL/6 * SJL
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Adgrg6em3Jlp mutation (0 available); any Adgrg6 mutation (65 available)
Tg(Tek-cre)1Ywa mutation (6 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
normal phenotype
no abnormal phenotype detected ( J:315981 )
• embryos are viable throughout embryogenesis with no resorptions noted from E11.5 to E18.5 and no cardiac defects detected at E15.5
• adult mice show normal electrocardiogram values and left ventricular function with no significant differences in heart size (heart weight-to-tibia length ratio) or in cardiac histology relative to control mice




Genotype
MGI:7442268
cn6
Allelic
Composition		 Adgrg6em2Jlp/Adgrg6em3Jlp
Tg(Tek-cre)1Ywa/0
Genetic
Background		 involves: C57BL/6 * SJL
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Adgrg6em2Jlp mutation (0 available); any Adgrg6 mutation (65 available)
Adgrg6em3Jlp mutation (0 available); any Adgrg6 mutation (65 available)
Tg(Tek-cre)1Ywa mutation (6 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
normal phenotype
no abnormal phenotype detected ( J:315981 )
• mice exhibit no evidence of embryonic lethality; no cardiac defects are detected at E16.5




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Send questions and comments to User Support. 		last database update
11/12/2024
MGI 6.24 		The Jackson Laboratory