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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Gt(ROSA)26Sortm1(ADGRG6)Jlp
targeted mutation 1, Jose Luis de la Pompa
MGI:7438178
Summary 3 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
cn1
 		Adgrg6em2Jlp/Adgrg6em2Jlp
Edil3Tg(Sox2-cre)1Amc/Edil3+
Gt(ROSA)26Sortm1(ADGRG6)Jlp/Gt(ROSA)26Sor+ 		involves: 129S6/SvEvTac * C57BL/6 * C57BL/6NCrl * CBA MGI:7442280
cn2
 		Gt(ROSA)26Sortm1(ADGRG6)Jlp/Gt(ROSA)26Sor+
Tg(Tek-cre)1Ywa/0 		involves: 129S6/SvEvTac * C57BL/6 * C57BL/6NCrl * SJL MGI:7442271
cn3
 		Adgrg6em2Jlp/Adgrg6em2Jlp
Gt(ROSA)26Sortm1(ADGRG6)Jlp/Gt(ROSA)26Sor+
Tg(Tek-cre)1Ywa/0 		involves: 129S6/SvEvTac * C57BL/6 * C57BL/6NCrl * SJL MGI:7442273


Genotype
MGI:7442280
cn1
Allelic
Composition		 Adgrg6em2Jlp/Adgrg6em2Jlp
Edil3Tg(Sox2-cre)1Amc/Edil3+
Gt(ROSA)26Sortm1(ADGRG6)Jlp/Gt(ROSA)26Sor+
Genetic
Background		 involves: 129S6/SvEvTac * C57BL/6 * C57BL/6NCrl * CBA
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Adgrg6em2Jlp mutation (0 available); any Adgrg6 mutation (63 available)
Edil3Tg(Sox2-cre)1Amc mutation (5 available); any Edil3 mutation (42 available)
Gt(ROSA)26Sortm1(ADGRG6)Jlp mutation (0 available); any Gt(ROSA)26Sor mutation (968 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging
lethality throughout fetal growth and development, incomplete penetrance ( J:315981 )
• when the cre transgene is inherited maternally, embryos survive to birth, regardless of the presence of the Cre transgene
embryonic lethality during organogenesis, complete penetrance ( J:315981 )
• when the cre transgene is inherited paternally, embryos do not survive past E13.5

nervous system
nervous system phenotype ( J:315981 )
N
• when the cre transgene is inherited maternally, no PNS-related phenotypes are observed




Genotype
MGI:7442271
cn2
Allelic
Composition		 Gt(ROSA)26Sortm1(ADGRG6)Jlp/Gt(ROSA)26Sor+
Tg(Tek-cre)1Ywa/0
Genetic
Background		 involves: 129S6/SvEvTac * C57BL/6 * C57BL/6NCrl * SJL
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gt(ROSA)26Sortm1(ADGRG6)Jlp mutation (0 available); any Gt(ROSA)26Sor mutation (968 available)
Tg(Tek-cre)1Ywa mutation (6 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
normal phenotype
no abnormal phenotype detected ( J:315981 )
• embryos are viable and show normal heart development at E10.5, E13.5 and E16.5




Genotype
MGI:7442273
cn3
Allelic
Composition		 Adgrg6em2Jlp/Adgrg6em2Jlp
Gt(ROSA)26Sortm1(ADGRG6)Jlp/Gt(ROSA)26Sor+
Tg(Tek-cre)1Ywa/0
Genetic
Background		 involves: 129S6/SvEvTac * C57BL/6 * C57BL/6NCrl * SJL
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Adgrg6em2Jlp mutation (0 available); any Adgrg6 mutation (63 available)
Gt(ROSA)26Sortm1(ADGRG6)Jlp mutation (0 available); any Gt(ROSA)26Sor mutation (968 available)
Tg(Tek-cre)1Ywa mutation (6 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging
embryonic lethality during organogenesis, complete penetrance ( J:315981 )
• embryos die predominantly at E13.5, similar to embryos homozygous for the Adgrg6em2Jlp allele




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Send questions and comments to User Support. 		last database update
07/05/2024
MGI 6.24 		The Jackson Laboratory