All Phenotypes Setd5<tm1c(EUCOMM)Wtsi> MGI Mouse

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Phenotypes associated with this allele

Allele Symbol
Allele Name
Allele ID

Setd5^{tm1c(EUCOMM)Wtsi}
targeted mutation 1c, Wellcome Trust Sanger Institute
MGI:7438258

Summary

5 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
cn1	Setd5^{tm1c(EUCOMM)Wtsi}/Setd5⁺ Tbx1^tm1Bld/Tbx1⁺ Tmem163^{Tg(ACTB-cre)2Mrt}/Tmem163⁺	involves: 129S7/SvEvBrd * C57BL/6 * FVB/N	MGI:7543763
cn2	Setd5^{tm1c(EUCOMM)Wtsi}/Setd5^{tm1c(EUCOMM)Wtsi} Tbx1^tm6(cre)Bld/Tbx1⁺	involves: C57BL/6N	MGI:7543765
cn3	Setd5^{tm1c(EUCOMM)Wtsi}/Setd5^{tm1c(EUCOMM)Wtsi} Mesp1^tm2(cre)Ysa/Mesp1⁺	involves: C57BL/6N * C57BL/6NCrlj * CBA/JNCrlj	MGI:7543766
cn4	Setd5^{tm1c(EUCOMM)Wtsi}/Setd5⁺ Mesp1^tm2(cre)Ysa/Mesp1⁺	involves: C57BL/6N * C57BL/6NCrlj * CBA/JNCrlj	MGI:7543767
cn5	Setd5^{tm1c(EUCOMM)Wtsi}/Setd5⁺ Tmem163^{Tg(ACTB-cre)2Mrt}/Tmem163⁺	involves: C57BL/6N * FVB/N	MGI:7543762

Allelic Composition	Setd5^{tm1c(EUCOMM)Wtsi}/Setd5⁺ Tbx1^tm1Bld/Tbx1⁺ Tmem163^{Tg(ACTB-cre)2Mrt}/Tmem163⁺
Genetic Background	involves: 129S7/SvEvBrd * C57BL/6 * FVB/N

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Setd5^{tm1c(EUCOMM)Wtsi} mutation (0 available); any Setd5 mutation (122 available)
Tbx1^tm1Bld mutation (1 available); any Tbx1 mutation (36 available)
Tmem163^{Tg(ACTB-cre)2Mrt} mutation (3 available); any Tmem163 mutation (37 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

mortality/aging ( J:314464 )

N	• double heterozygotes are recovered at normal Mendelian ratios at E14.5

cardiovascular system

abnormal right subclavian artery morphology ( J:314464 )

• at E14.5, 21% of double heterozygotes exhibit an aberrant right subclavian artery

abnormal cardiac outflow tract development ( J:314464 )

• at E14.5, 57% of double heterozygotes show OFT rotational defects, including DORV and overriding aorta

• however, no common arterial trunk is identified at E14.5

double outlet right ventricle ( J:314464 )

overriding aortic valve ( J:314464 )

perimembraneous ventricular septal defect ( J:314464 )

• at E14.5, 86% of double heterozygotes exhibit a perimembranous VSD

Allelic Composition	Setd5^{tm1c(EUCOMM)Wtsi}/Setd5^{tm1c(EUCOMM)Wtsi} Tbx1^tm6(cre)Bld/Tbx1⁺
Genetic Background	involves: C57BL/6N

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Setd5^{tm1c(EUCOMM)Wtsi} mutation (0 available); any Setd5 mutation (122 available)
Tbx1^tm6(cre)Bld mutation (1 available); any Tbx1 mutation (36 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

cardiovascular system

cardiovascular system phenotype ( J:314464 )

N	• at E15.5, hearts show no great vessel defects; outflow tract septation is largely normal and the atrial septum and atrioventricular valves are intact

Allelic Composition	Setd5^{tm1c(EUCOMM)Wtsi}/Setd5^{tm1c(EUCOMM)Wtsi} Mesp1^tm2(cre)Ysa/Mesp1⁺
Genetic Background	involves: C57BL/6N * C57BL/6NCrlj * CBA/JNCrlj

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Mesp1^tm2(cre)Ysa mutation (3 available); any Mesp1 mutation (18 available)
Setd5^{tm1c(EUCOMM)Wtsi} mutation (0 available); any Setd5 mutation (122 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

embryonic lethality during organogenesis, complete penetrance ( J:314464 )

• embryos are recovered at expected Mendelian ratios at E10.5 but die before E12.5

growth/size/body

decreased embryo size ( J:314464 )

• at E10.5, embryos are significantly smaller than control embryos, as determined by crown-to-rump length

embryo

decreased embryo size ( J:314464 )

• at E10.5, embryos are significantly smaller than control embryos, as determined by crown-to-rump length

cardiovascular system

abnormal cardiac outflow tract development ( J:314464 )

• at E10.5, all (100%) of hearts exhibit a shorter OFT than control hearts

abnormal heart morphology ( J:314464 )

• at E10.5, embryos show varying degrees of abnormal cardiac morphogenesis

abnormal heart atrium morphology ( J:314464 )

• at E10.5, some embryos show poorly developed atria and a thickened atrial wall

common atrium ( J:314464 )

common ventricle ( J:314464 )

abnormal heart shape ( J:314464 )

• at E10.5, 25% of embryos have dumbbell-shaped hearts with a single atrium and a single ventricle

heart right ventricle hypoplasia ( J:314464 )

• at E10.5, some embryos exhibit right ventricular hypoplasia

abnormal interventricular groove morphology ( J:314464 )

• at E10.5, some embryos show no evidence of the interventricular groove

pericardial effusion ( J:314464 )

• at E10.5, 74% of embryos exhibit pericardial effusion

dilated heart ( J:314464 )

• at E10.5, 95% of embryos show abnormal cardiac chamber ballooning by external analysis

dilated heart atrium ( J:314464 )

• at E10.5, all (100%) hearts show abnormal atrial ballooning by H&E analysis

dilated heart ventricle ( J:314464 )

• at E10.5, all (100%) hearts show abnormal ventricular ballooning by H&E analysis

hemorrhage ( J:314464 )

• at E10.5, 16% of embryos exhibit hemorrhage

homeostasis/metabolism

pericardial effusion ( J:314464 )

• at E10.5, 74% of embryos exhibit pericardial effusion

Allelic Composition	Setd5^{tm1c(EUCOMM)Wtsi}/Setd5⁺ Mesp1^tm2(cre)Ysa/Mesp1⁺
Genetic Background	involves: C57BL/6N * C57BL/6NCrlj * CBA/JNCrlj

Find Mice

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

cardiovascular system

dilated heart ventricle ( J:314464 )

• at E10.5, one of 6 (17%) hearts show abnormal ventricular ballooning

• however, no OFT phenotype or abnormal atrial ballooning is observed

Allelic Composition	Setd5^{tm1c(EUCOMM)Wtsi}/Setd5⁺ Tmem163^{Tg(ACTB-cre)2Mrt}/Tmem163⁺
Genetic Background	involves: C57BL/6N * FVB/N

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Setd5^{tm1c(EUCOMM)Wtsi} mutation (0 available); any Setd5 mutation (122 available)
Tmem163^{Tg(ACTB-cre)2Mrt} mutation (3 available); any Tmem163 mutation (37 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

cardiovascular system

abnormal cardiac outflow tract development ( J:314464 )

• at E14.5, 50% of heterozygotes show outflow tract (OFT) rotational defects (OFT fails to align with the two future ventricles at the looping stage), including DORV and overriding aorta

• however, OFT septation is normal; no aberrant right subclavian artery or common arterial trunk are identified at E14.5

double outlet right ventricle ( J:314464 )

• at E14.5

overriding aortic valve ( J:314464 )

• at E14.5

perimembraneous ventricular septal defect ( J:314464 )

• at E14.5, 75% of heterozygotes exhibit a perimembranous VSD

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