immune system
N |
• normal reaction to Leishmania major (L. major) infection
• normal T cell development
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Allele Symbol Allele Name Allele ID |
Rr386em1Pdi endonuclease-mediated mutation 1, Priya D Issuree MGI:7439579 |
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Summary |
2 genotypes
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♀ | phenotype observed in females |
♂ | phenotype observed in males |
N | normal phenotype |
N |
• normal reaction to Leishmania major (L. major) infection
• normal T cell development
|
|
|
♀ | phenotype observed in females |
♂ | phenotype observed in males |
N | normal phenotype |
• lower frequency and number of Tbet+ CD11a-hi CD44+ helper T cells in draining lymph nodes (dLNs) 28 days after infection with Leishmania major (L. major)
|
• delayed swelling of cutaneous infection point after infection with Leishmania major (L. major)
• increased parasitic burden 28 and 54 days after infection with Leishmania major (L. major)
• Leishmania major (L. major) infection lesions resolved in normal time
• normal parasitic burden 9 days after infection with Leishmania major (L. major)
|
N |
• normal proportions of CD11a-hi CD49d+ and CD11a-hi CD44+ T cells in draining lymph nodes (dLNs) 9 days after infection with Leishmania major (L. major)
• normal frequency of GATA3+ CD11a-hi CD44+ T cells in draining lymph nodes (dLNs) 28 days after infection with Leishmania major (L. major)
• normal absolute T cell numbers in draining lymph nodes (dLNs) 28 days after infection with Leishmania major (L. major)
|
• lower frequency and number of Tbet+ CD11a-hi CD44+ helper T cells in draining lymph nodes (dLNs) 28 days after infection with Leishmania major (L. major)
|
• delayed swelling of cutaneous infection point after infection with Leishmania major (L. major)
• increased parasitic burden 28 and 54 days after infection with Leishmania major (L. major)
• Leishmania major (L. major) infection lesions resolved in normal time
• normal parasitic burden 9 days after infection with Leishmania major (L. major)
|
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO) |
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last database update 10/29/2024 MGI 6.24 |
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