Phenotypes associated with this allele

• Allele Symbol: Cep70^em1Qiao
• Allele Name: endonuclease-mediated mutation 1, Jie Qiao
• Allele ID: MGI:7439755
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Cep70^em1Qiao/Cep70^em1Qiao	C57BL/6J-Cep70^em1Qiao	MGI:7439763

Genotype
MGI:7439763

hm1

• Allelic Composition: Cep70^em1Qiao/Cep70^em1Qiao
• Genetic Background: C57BL/6J-Cep70^em1Qiao

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

reproductive system

reproductive system phenotype ( J:333258 )

♀N • female mice exhibit normal fertility

azoospermia ( J:333258 )

♂ • seminiferous tubules lack elongated spermatids

♂ • however, spermatocytes and round spermatids are present

teratozoospermia ( J:333258 )

♂

coiled sperm flagellum ( J:333258 )

♂

kinked sperm flagellum ( J:333258 )

♂ • bent and wrinkled

short sperm flagellum ( J:333258 )

♂

abnormal acrosome morphology ( J:333258 )

♂ • vacuolated or irregularly shaped

small sperm head ( J:333258 )

♂ • with irregular shape

increased male germ cell apoptosis ( J:333258 )

♂

small testis ( J:333258 )

♂

decreased testis weight ( J:333258 )

♂

arrest of spermiogenesis ( J:333258 )

♂ • blocked at stages VII and VIII

male infertility ( J:333258 )

♂

endocrine/exocrine glands

small testis ( J:333258 )

♂

decreased testis weight ( J:333258 )

♂

cellular

azoospermia ( J:333258 )

♂ • seminiferous tubules lack elongated spermatids

♂ • however, spermatocytes and round spermatids are present

teratozoospermia ( J:333258 )

♂

coiled sperm flagellum ( J:333258 )

♂

kinked sperm flagellum ( J:333258 )

♂ • bent and wrinkled

short sperm flagellum ( J:333258 )

♂

abnormal acrosome morphology ( J:333258 )

♂ • vacuolated or irregularly shaped

small sperm head ( J:333258 )

♂ • with irregular shape

increased male germ cell apoptosis ( J:333258 )

♂