Phenotypes associated with this allele

• Allele Symbol: Fer1l5^tm1Osb
• Allele Name: targeted mutation 1, Research Institute for Microbial Diseases, Osaka University
• Allele ID: MGI:7439947
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Fer1l5^tm1Osb/Fer1l5^tm1Osb	STOCK Fer1l5^tm1Osb/75Osb	MGI:7441950

Genotype
MGI:7441950

hm1

• Allelic Composition: Fer1l5^tm1Osb/Fer1l5^tm1Osb
• Genetic Background: STOCK Fer1l5^tm1Osb/75Osb

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

reproductive system

reproductive system phenotype ( J:333204 )

♀N • female mice are fertile

reduced male fertility ( J:333204 )

♂ • male fertility is severely impaired

♂ • however, transgenic expression of a FLAG or PA-tagged versions rescues fertility

impaired acrosome reaction ( J:333204 )

♂ • spermatozoa cannot undergo the acrosome reaction in vitro or in vivo

♂ • however, transgenic expression of a FLAG or PA-tagged versions rescues acrosome reaction

failure of sperm-egg fusion ( J:333204 )

♂

impaired sperm penetration of zona pellucida ( J:333204 )

♂