Phenotypes associated with this allele

• Allele Symbol: Rr388^em1Zyliu
• Allele Name: endonuclease-mediated mutation 1, Zhiyong Liu
• Allele ID: MGI:7440077
• Summary: 2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
cx1	Rr387^em1Zyliu/Rr387^em1Zyliu Rr388^em1Zyliu/Rr388^em1Zyliu	Not Specified	MGI:7447205
cx2	Rr387^em1Zyliu/Rr387^em1Zyliu Rr388^em1Zyliu/Rr388^em1Zyliu Rr397^em1Zyliu/Rr397^em1Zyliu	Not Specified	MGI:7447208

Genotype
MGI:7447205

cx1

• Allelic Composition: Rr387^em1Zyliu/Rr387^em1Zyliu; Rr388^em1Zyliu/Rr388^em1Zyliu
• Genetic Background: Not Specified

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

hearing/vestibular/ear

hearing/vestibular/ear phenotype ( J:333396 )

N • normal cochlear length at age P1

decreased cochlear outer hair cell number ( J:333396 )

• 93% lower density in all turns at age P1 and 98% at age P30

increased or absent threshold for auditory brainstem response ( J:333396 )

• at all frequencies

embryo

embryo phenotype ( J:333396 )

N • viable

mortality/aging

mortality/aging ( J:333396 )

N • viable

premature death ( J:333396 )

• mice die around age P35

nervous system

decreased cochlear outer hair cell number ( J:333396 )

• 93% lower density in all turns at age P1 and 98% at age P30

abnormal cerebellum development ( J:333396 )

• abnormal morphology at age P30

Genotype
MGI:7447208

cx2

• Allelic Composition: Rr387^em1Zyliu/Rr387^em1Zyliu; Rr388^em1Zyliu/Rr388^em1Zyliu; Rr397^em1Zyliu/Rr397^em1Zyliu
• Genetic Background: Not Specified

hearing/vestibular/ear

hearing/vestibular/ear phenotype ( J:333396 )

N • normal cochlear length at age P1

decreased cochlear hair cell number ( J:333396 )

• 97% lower density in all turns at age P1

embryo

embryo phenotype ( J:333396 )

N • viable

mortality/aging

mortality/aging ( J:333396 )

N • viable

nervous system

decreased cochlear hair cell number ( J:333396 )

• 97% lower density in all turns at age P1