Analysis Tools
immune system
| N |
• in the myelin oligodendrocyte glycoprotein (MOG)-induced autoimmune encephalomyelitis (EAE) model, mice exhibit only a mild, statistically non-significant improvement of EAE progression relative to wild-type controls, based on the combined severity score
|
|
• at 8-12 weeks of age, mice show no major changes in their B cell compartment, except for very mildly increased frequencies of B cells in the lymph nodes, but not in spleen
|
|
• at 8-12 weeks of age, mice show no major changes in their T cell compartment, except for very mildly decreased frequencies of naive (CD44-) CD8+ T cells in the lymph nodes, but not in spleen
|
|
• following intraperitoneal injection of IL-17A, mice show a significantly weaker recruitment of CD45+CD11b+Ly6G+ neutrophils and CD45+CD11b+Ly6GLy6C+ inflammatory monocytes than wild-type mice
• in contrast, intraperitoneal residual CD45+CD11b+F4/80+ macrophages remain unchanged
|
|
• in the imiquimod (IMQ)-induced experimental model of psoriasis, mice exhibit a lower score for dorsal skin erythema, scaling and thickness on days 3 and 4, and reduced ear skin thickness on days 2-5 relative to wild-type controls
• after 4 days of IMQ treatment, ear skin shows less severe pathology with markedly lower expression of IL-17A target genes than in wild-type controls
|
cellular
|
• mouse embryonic fibroblasts (MEFs) show impaired IL-17-induced signaling measured as phosphorylation of p38, JNK and TBK1, along with a reduced amount of IL-17 receptor subunit C (IL-17RC) protein and IL-17RC glycosylation relative to wild-type MEFs
|
integument
|
• in the imiquimod (IMQ)-induced experimental model of psoriasis, mice exhibit a lower score for dorsal skin erythema, scaling and thickness on days 3 and 4, and reduced ear skin thickness on days 2-5 relative to wild-type controls
• after 4 days of IMQ treatment, ear skin shows less severe pathology with markedly lower expression of IL-17A target genes than in wild-type controls
|
|
• primary keratinocytes isolated from the mouse tail show markedly reduced surface expression of IL-17RC relative to wild-type keratinocytes
|
hematopoietic system
|
• at 8-12 weeks of age, mice show no major changes in their B cell compartment, except for very mildly increased frequencies of B cells in the lymph nodes, but not in spleen
|
|
• at 8-12 weeks of age, mice show no major changes in their T cell compartment, except for very mildly decreased frequencies of naive (CD44-) CD8+ T cells in the lymph nodes, but not in spleen
|
