Phenotypes associated with this allele

• Allele Symbol: Abat^{tm1c(EUCOMM)Hmgu}
• Allele Name: targeted mutation 1c, Helmholtz Zentrum Muenchen GmbH
• Allele ID: MGI:7443008
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
cn1	Abat^tm1c(EUCOMM)Hmgu/Abat^tm1c(EUCOMM)Hmgu Tg(Cd4-cre)1Cwi/0	involves: 129S4/SvJaeSor * C57BL/6 * C57BL/6N * DBA/2	MGI:7642163

Genotype
MGI:7642163

cn1

• Allelic Composition: Abat^{tm1c(EUCOMM)Hmgu}/Abat^{tm1c(EUCOMM)Hmgu}; Tg(Cd4-cre)1Cwi/0
• Genetic Background: involves: 129S4/SvJaeSor * C57BL/6 * C57BL/6N * DBA/2

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

immune system

immune system phenotype ( J:333883 )

N • no defects in T cell development in the thymus, spleen, or lymph nodes are dectected

N • no alteration in cell viability, expression of cell surface activation markers, cell cycle progression, or cell size

decreased T cell proliferation ( J:333883 )

• moderate suppression of overall proliferation after activation in vitro

abnormal CD4-positive T cell differentiation ( J:333883 )

• enhanced anti-inflammatory induced T regulatory cell differentiation in vitro

abnormal T-helper 1 cell differentiation ( J:333883 )

• inhibition in vitro

• however, there is no significant change in Th2 cell differentiation in vitro

abnormal T-helper 17 cell differentiation ( J:333883 )

• inhibition of differentiation in vitro

• treatment with NV118 (cell permeable succinate analogue) partially restores differentiation

abnormal CD4-positive, CD25-positive, alpha-beta regulatory T cell morphology ( J:333883 )

• enhanced anti-inflammatory induced T regulatory cell differentiation in vitro

decreased susceptibility to experimental autoimmune encephalomyelitis ( J:333883 )

• significant protection from EAE pathogenic progression with more infiltrated FoxP3+CD4+ T cells and fewer infiltrated inflammatory CD4+T cells

cellular

decreased T cell proliferation ( J:333883 )

• moderate suppression of overall proliferation after activation in vitro

hematopoietic system

decreased T cell proliferation ( J:333883 )

• moderate suppression of overall proliferation after activation in vitro

abnormal CD4-positive T cell differentiation ( J:333883 )

• enhanced anti-inflammatory induced T regulatory cell differentiation in vitro

abnormal T-helper 1 cell differentiation ( J:333883 )

• inhibition in vitro

• however, there is no significant change in Th2 cell differentiation in vitro

abnormal T-helper 17 cell differentiation ( J:333883 )

• inhibition of differentiation in vitro

• treatment with NV118 (cell permeable succinate analogue) partially restores differentiation

abnormal CD4-positive, CD25-positive, alpha-beta regulatory T cell morphology ( J:333883 )

• enhanced anti-inflammatory induced T regulatory cell differentiation in vitro