Phenotypes associated with this allele

• Allele Symbol: Pla2g4e^em1Murm
• Allele Name: endonuclease-mediated mutation 1, Makoto Murakami
• Allele ID: MGI:7444531
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Pla2g4e^em1Murm/Pla2g4e^em1Murm	C57BL/6NSlc-Pla2g4e^em1Murm	MGI:7444766

Genotype
MGI:7444766

hm1

• Allelic Composition: Pla2g4e^em1Murm/Pla2g4e^em1Murm
• Genetic Background: C57BL/6NSlc-Pla2g4e^em1Murm

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

integument

increased susceptibility to chemically induced skin inflammation ( J:333700 )

• imiquimod-challenged mice exhibit increased ear swelling with more severe epidermal hyperplasia, dermal swelling, and inflammatory cell infiltration compared with wild-type mice

abnormal skin morphology ( J:333700 )

• reduced N-acylethanolamine-related lipids in the skin whether mice are untreated or treated with imiquimod

epidermal hyperplasia ( J:333700 )

• more severe in imiquimod-challenged mice

immune system

increased susceptibility to chemically induced skin inflammation ( J:333700 )

• imiquimod-challenged mice exhibit increased ear swelling with more severe epidermal hyperplasia, dermal swelling, and inflammatory cell infiltration compared with wild-type mice

homeostasis/metabolism

abnormal lipid level ( J:333700 )

• reduced N-acylethanolamine-related lipids in the skin whether mice are untreated or treated with imiquimod