Phenotypes associated with this allele

• Allele Symbol: Fbxo21^em1Smbk
• Allele Name: endonuclease-mediated mutation 1, Shannon M Buckley
• Allele ID: MGI:7444787
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
cn1	Fbxo21^em1Smbk/Fbxo21^em1Smbk Commd10^Tg(Vav1-icre)A2Kio/Commd10^+	B6.Cg-Fbxo21^em1Smbk Commd10^Tg(Vav1-icre)A2Kio	MGI:7444791

Genotype
MGI:7444791

cn1

• Allelic Composition: Fbxo21^em1Smbk/Fbxo21^em1Smbk; Commd10^{Tg(Vav1-icre)A2Kio}/Commd10⁺
• Genetic Background: B6.Cg-Fbxo21^em1Smbk Commd10^{Tg(Vav1-icre)A2Kio}

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

increased susceptibility to induced morbidity/mortality ( J:333469 )

• in 5-FU-treated mice

hematopoietic system

abnormal stress erythropoiesis ( J:333469 )

• 5-FU-treated mice exhibit increased bone marrow failure and lethality compared with wild-type mice

increased granulocyte monocyte progenitor cell number ( J:333469 )

• in the bone marrow

increased T cell number ( J:333469 )

• in the bone marrow but not peripheral blood

decreased spleen weight ( J:333469 )

• slightly

abnormal bone marrow cell physiology ( J:333469 )

• slightly decreased CFY potential in vitro

• however, steady-state hematopoiesis and performance in competitive repopulation assay are normal

immune system

increased T cell number ( J:333469 )

• in the bone marrow but not peripheral blood

decreased spleen weight ( J:333469 )

• slightly