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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Rnf148em2Zuk
endonuclease-mediated mutation 2, Martin M Matzuk
MGI:7446290
Summary 1 genotype
Jump to Allelic Composition Genetic Background Genotype ID
cx1
 		Rnf133em1Zuk/Rnf133em1Zuk
Rnf148em2Zuk/Rnf148em2Zuk 		involves: 129S5/SvEvBrd * C57BL/6NCrl * DBA/2NCrl MGI:7734999


Genotype
MGI:7734999
cx1
Allelic
Composition		 Rnf133em1Zuk/Rnf133em1Zuk
Rnf148em2Zuk/Rnf148em2Zuk
Genetic
Background		 involves: 129S5/SvEvBrd * C57BL/6NCrl * DBA/2NCrl
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Rnf133em1Zuk mutation (0 available); any Rnf133 mutation (12 available)
Rnf148em2Zuk mutation (0 available); any Rnf148 mutation (26 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
reproductive system
teratozoospermia ( J:330415 )
• 82-fold increase in the percentage of abnormal morphology immotile sperm
hairpin sperm flagellum ( J:330415 )
• sperm exhibit abnormal morphologies, including bending at the head/midpiece and bending at the midpiece/principal piece
abnormal sperm head morphology ( J:330415 )
• testes show an increase in sperm nuclei surrounded by excess cytoplasm at stage IX (89.2% percent of sperm vs. 20.5% of sperm in controls)
asthenozoospermia ( J:330415 )
• decrease in the percentage of motile sperm and progressive motility
• 2.5-fold decrease in the percentage of normal morphology motile sperm
• 12.8-fold increase in the percentage of normal morphology immotile sperm
• 82-fold increase in the percentage of abnormal morphology immotile sperm
decreased hyperactivated sperm motility ( J:330415 )
• sperm do not show a dramatic change in hyperactivation when incubated in capacitation medium
reduced male fertility ( J:330415 )
• males are subfertile; homozygous males mated with wild-type females produce fewer pups per litter
• subfertility remains at a similar level as single Rnf133 null males
• however, spermatogenesis is grossly normal and males exhibit normal testicular size, weight and caudal epididymal sperm

cellular
teratozoospermia ( J:330415 )
• 82-fold increase in the percentage of abnormal morphology immotile sperm
hairpin sperm flagellum ( J:330415 )
• sperm exhibit abnormal morphologies, including bending at the head/midpiece and bending at the midpiece/principal piece
abnormal sperm head morphology ( J:330415 )
• testes show an increase in sperm nuclei surrounded by excess cytoplasm at stage IX (89.2% percent of sperm vs. 20.5% of sperm in controls)
asthenozoospermia ( J:330415 )
• decrease in the percentage of motile sperm and progressive motility
• 2.5-fold decrease in the percentage of normal morphology motile sperm
• 12.8-fold increase in the percentage of normal morphology immotile sperm
• 82-fold increase in the percentage of abnormal morphology immotile sperm
decreased hyperactivated sperm motility ( J:330415 )
• sperm do not show a dramatic change in hyperactivation when incubated in capacitation medium




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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
11/19/2024
MGI 6.24 		The Jackson Laboratory