Phenotypes associated with this allele

• Allele Symbol: Insm2^em1Tcai
• Allele Name: endonuclease-mediated mutation 1, Tao Cai
• Allele ID: MGI:7446800
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Insm2^em1Tcai/Insm2^em1Tcai	involves: C57BL/6J	MGI:7446808

Genotype
MGI:7446808

hm1

• Allelic Composition: Insm2^em1Tcai/Insm2^em1Tcai
• Genetic Background: involves: C57BL/6J

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

reproductive system

reduced female fertility ( J:334013 )

• female fertility is reduced; after mating with males, only 31.25% of females give birth but with a smaller litter size (4 vs. 9 in controls)

decreased litter size ( J:334013 )

• after mating with males, only 31.25% of females give birth but with a smaller litter size (4 vs. 9 in controls)

homeostasis/metabolism

abnormal blood homeostasis ( J:334013 )

• basal blood C-peptide levels are decreased

increased fasting circulating glucose level ( J:334013 )

• fasting blood glucose levels of males at 16 weeks of age and of females at 16 and 24 weeks of age are elevated

decreased circulating insulin level ( J:334013 )

impaired glucose tolerance ( J:334013 )

• glucose tolerance tests show elevated glucose levels in both males and females indicating a reduction in glucose tolerance

endocrine/exocrine glands

endocrine/exocrine gland phenotype ( J:334013 )

N • pancreatic tissue shows no alterations in number and size of islets

growth/size/body

growth/size/body region phenotype ( J:334013 )

N • body weight at 8, 16, and 24 weeks of age is normal