Phenotypes associated with this allele

• Allele Symbol: Hpdl^em1Jgg
• Allele Name: endonuclease-mediated mutation 1, Joseph Gleeson
• Allele ID: MGI:7447439
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Hpdl^em1Jgg/Hpdl^em1Jgg	C57BL/6-Hpdl^em1Jgg	MGI:7447442

Genotype
MGI:7447442

hm1

• Allelic Composition: Hpdl^em1Jgg/Hpdl^em1Jgg
• Genetic Background: C57BL/6-Hpdl^em1Jgg

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

postnatal lethality, complete penetrance ( J:334229 )

• most mice die by P10 and all by P15

nervous system

seizures ( J:334229 )

• at P5

increased neuron apoptosis ( J:334229 )

neurodegeneration ( J:334229 )

behavior/neurological

lethargy ( J:334229 )

• at P5

seizures ( J:334229 )

• at P5

growth/size/body

decreased body weight ( J:334229 )

• by P9 and P10

cellular

increased neuron apoptosis ( J:334229 )

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
neurodegenerative disease		DOID:1289		J:334229