Phenotypes associated with this allele

• Allele Symbol: Cfap61^em1Yqt
• Allele Name: endonuclease-mediated mutation 1, Yue-Qiu Tan
• Allele ID: MGI:7448443
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Cfap61^em1Yqt/Cfap61^em1Yqt	C57BL/6-Cfap61^em1Yqt	MGI:7448446

Genotype
MGI:7448446

hm1

• Allelic Composition: Cfap61^em1Yqt/Cfap61^em1Yqt
• Genetic Background: C57BL/6-Cfap61^em1Yqt

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

reproductive system

abnormal sperm flagellum morphology ( J:333342 )

• sperm show multiple morphological abnormalities including coiled flagella, short flagella, irregular flagella, and absent flagella

• components of the spermatozoa flagellum are disordered within the cytoplasm

• sperm flagellum shows hypertrophy and hyperplasia of mitochondria

abnormal outer dense fiber morphology ( J:333342 )

• sperm flagellum shows disarrangement and hyperplasia of outer dense fibers

abnormal sperm axoneme morphology ( J:333342 )

• 53.33% of mice show a central pair structure defect in sperm flagella

• 66.67% of males show distortion of various periaxonemal microtuble components in sperm flagella

absent sperm flagellum ( J:333342 )

coiled sperm flagellum ( J:333342 )

short sperm flagellum ( J:333342 )

oligozoospermia ( J:333342 )

• the daily sperm production is slightly decreased

• sperm counts in the seminiferous tubules and especially in epididymis are decreased

increased testis apoptosis ( J:333342 )

• apoptotic cells are more abundant in the testes

decreased sperm progressive motility ( J:333342 )

• sperm progressive motility is dramatically lower

asthenozoospermia ( J:333342 )

• sperm motility rate is dramatically lower

male infertility ( J:333342 )

• males father no offspring during a 3-month mating period

• however, no reductions in the size and weight of testes are seen

endocrine/exocrine glands

increased testis apoptosis ( J:333342 )

• apoptotic cells are more abundant in the testes

cellular

abnormal sperm flagellum morphology ( J:333342 )

• sperm show multiple morphological abnormalities including coiled flagella, short flagella, irregular flagella, and absent flagella

• components of the spermatozoa flagellum are disordered within the cytoplasm

• sperm flagellum shows hypertrophy and hyperplasia of mitochondria

abnormal outer dense fiber morphology ( J:333342 )

• sperm flagellum shows disarrangement and hyperplasia of outer dense fibers

abnormal sperm axoneme morphology ( J:333342 )

• 53.33% of mice show a central pair structure defect in sperm flagella

• 66.67% of males show distortion of various periaxonemal microtuble components in sperm flagella

absent sperm flagellum ( J:333342 )

coiled sperm flagellum ( J:333342 )

short sperm flagellum ( J:333342 )

oligozoospermia ( J:333342 )

• the daily sperm production is slightly decreased

• sperm counts in the seminiferous tubules and especially in epididymis are decreased

increased testis apoptosis ( J:333342 )

• apoptotic cells are more abundant in the testes

decreased sperm progressive motility ( J:333342 )

• sperm progressive motility is dramatically lower

asthenozoospermia ( J:333342 )

• sperm motility rate is dramatically lower

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
oligoasthenoteratozoospermia		DOID:0070311		J:333342