Phenotypes associated with this allele

• Allele Symbol: Rr401^em1Yushi
• Allele Name: endonuclease-mediated mutation 1, Yuichi Shima
• Allele ID: MGI:7448545
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Rr401^em1Yushi/Rr401^em1Yushi	Not Specified	MGI:7448597

Genotype
MGI:7448597

hm1

• Allelic Composition: Rr401^em1Yushi/Rr401^em1Yushi
• Genetic Background: Not Specified

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

reproductive system

reproductive system phenotype ( J:334319 )

♂N • normal testis size and descendance and vas deferens development in E18.5 embryos

oligozoospermia ( J:334319 )

♂ • few mature spermatozoa in seminiferous tubules in adult mice

absent seminal vesicle ( J:334319 )

♂ • mostly replaced with adipose tissue in adult mice

decreased corpora lutea number ( J:334319 )

♀ • in adult mice

abnormal ovarian folliculogenesis ( J:334319 )

♀ • many traces of closed follicles in adult mice

small ovary ( J:334319 )

♀ • in adult mice

small seminiferous tubules ( J:334319 )

♂ • reduced diameter in adult mice

abnormal Leydig cell morphology ( J:334319 )

♂ • fewer lipid droplets in interstitial Leydig cells in adult mice

small testis ( J:334319 )

♂ • in adult mice

abnormal testis tissue architecture ( J:334319 )

♂ • narrower testicular interstitium area in adult mice

small penis ( J:334319 )

♂ • in adult mice

infertility ( J:334319 )

female infertility ( J:334319 )

♀

male infertility ( J:334319 )

♂

endocrine/exocrine glands

endocrine/exocrine gland phenotype ( J:334319 )

♂N • normal adrenal gland size in E18.5 embryos

absent seminal vesicle ( J:334319 )

♂ • mostly replaced with adipose tissue in adult mice

decreased corpora lutea number ( J:334319 )

♀ • in adult mice

abnormal ovarian folliculogenesis ( J:334319 )

♀ • many traces of closed follicles in adult mice

small ovary ( J:334319 )

♀ • in adult mice

small seminiferous tubules ( J:334319 )

♂ • reduced diameter in adult mice

abnormal Leydig cell morphology ( J:334319 )

♂ • fewer lipid droplets in interstitial Leydig cells in adult mice

small testis ( J:334319 )

♂ • in adult mice

abnormal testis tissue architecture ( J:334319 )

♂ • narrower testicular interstitium area in adult mice

homeostasis/metabolism

homeostasis/metabolism phenotype ( J:334319 )

♂N • normal intratesticular testosterone, androstenedione and other steroid concentrations in E18.5 embryos

decreased circulating follicle stimulating hormone level ( J:334319 )

♀ • in adult mice

decreased sterol level ( J:334319 )

♂ • reduced intratesticular dehydroepiandrosterone, androstenediol, 7alpha-hydroxyandrostenedione, androstenedione and testosterone levels in adult mice

♂ • normal intratesticular testosterone, androstenedione and other steroid concentrations in E18.5 embryos

cellular

oligozoospermia ( J:334319 )

♂ • few mature spermatozoa in seminiferous tubules in adult mice

renal/urinary system

small penis ( J:334319 )

♂ • in adult mice

nervous system

nervous system phenotype ( J:334319 )

N • normal pituitary gland size in adult mice

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
infertility		DOID:5223		J:334319
male infertility		DOID:12336		J:334319