Phenotypes associated with this allele

• Allele Symbol: Srfbp1^em1(IMPC)J
• Allele Name: endonuclease-mediated mutation 1, Jackson
• Allele ID: MGI:7450824
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Srfbp1^em1(IMPC)J/Srfbp1^em1(IMPC)J	C57BL/6NJ-Srfbp1^em1(IMPC)J/Mmjax	MGI:7629107

Genotype
MGI:7629107

hm1

• Allelic Composition: Srfbp1^em1(IMPC)J/Srfbp1^em1(IMPC)J
• Genetic Background: C57BL/6NJ-Srfbp1^em1(IMPC)J/Mmjax

Data Sources

IMPC Data for Srfbp1

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

Srfbp1^em1(IMPC)J/Srfbp1^em1(IMPC)J mice exhibit embryonic lethality, with embryos recovered at E3.5 as compacting morulae but not at E7.5. Embryos fail to hatch from the zona pellucida and die after 3 days in culture.

mortality/aging

embryonic lethality before implantation, complete penetrance ( J:279207 )

• homozygous embryos can be recovered at E3.5 and appear as compacting morulae; no homozygous embryos or excess resorption sites are observed at E7.5

preweaning lethality, complete penetrance ( J:211773 )

IMPC - JAX

embryo

failure of blastocyst formation ( J:279207 )

• in vivo, embryos exhibit a compacting morula morphology at E3.5

• in vitro, embryos do not hatch and are dead after 3 days in culture

failure of blastocyst to hatch from the zona pellucida ( J:279207 )

• in vitro outgrowth assays show that embryos fail to hatch from the zona pellucida after 3 days in culture

embryonic growth retardation ( J:279207 )

• embryos recovered at E3.5 appear as compacting morulae

growth/size/body

embryonic growth retardation ( J:279207 )

• embryos recovered at E3.5 appear as compacting morulae