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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Srfbp1em1(IMPC)J
endonuclease-mediated mutation 1, Jackson
MGI:7450824
Summary 2 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Srfbp1em1(IMPC)J/Srfbp1em1(IMPC)J C57BL/6NJ-Srfbp1em1(IMPC)J/Mmjax MGI:7629107
ht2
 		Srfbp1em1(IMPC)J/Srfbp1+ C57BL/6NJ-Srfbp1em1(IMPC)J/Mmjax MGI:7768431


Genotype
MGI:7629107
hm1
Allelic
Composition		 Srfbp1em1(IMPC)J/Srfbp1em1(IMPC)J
Genetic
Background		 C57BL/6NJ-Srfbp1em1(IMPC)J/Mmjax
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Srfbp1em1(IMPC)J mutation (2 available); any Srfbp1 mutation (35 available)
Data Sources
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype

Srfbp1em1(IMPC)J/Srfbp1em1(IMPC)J mice exhibit embryonic lethality, with embryos recovered at E3.5 as compacting morulae but not at E7.5. Embryos fail to hatch from the zona pellucida and die after 3 days in culture.

embryo
failure of blastocyst formation ( J:279207 )
• in vivo, embryos exhibit a compacting morula morphology at E3.5
• in vitro, embryos do not hatch and are dead after 3 days in culture
failure of blastocyst to hatch from the zona pellucida ( J:279207 )
• in vitro outgrowth assays show that embryos fail to hatch from the zona pellucida after 3 days in culture
embryonic growth retardation ( J:279207 )
• embryos recovered at E3.5 appear as compacting morulae

growth/size/body
embryonic growth retardation ( J:279207 )
• embryos recovered at E3.5 appear as compacting morulae

mortality/aging
embryonic lethality before implantation, complete penetrance ( J:279207 )
• homozygous embryos can be recovered at E3.5 and appear as compacting morulae; no homozygous embryos or excess resorption sites are observed at E7.5




Genotype
MGI:7768431
ht2
Allelic
Composition		 Srfbp1em1(IMPC)J/Srfbp1+
Genetic
Background		 C57BL/6NJ-Srfbp1em1(IMPC)J/Mmjax
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Srfbp1em1(IMPC)J mutation (2 available); any Srfbp1 mutation (35 available)
Data Sources
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
hematopoietic system

immune system




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
12/17/2024
MGI 6.24 		The Jackson Laboratory