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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Sox9tm1.2Ksec
targeted mutation 1.2, Kathryn S E Cheah
MGI:7451121
Summary 2 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Sox9tm1.2Ksec/Sox9tm1.2Ksec involves: 129S/SvEv * C57BL/6 * FVB/N MGI:7451323
ht2
 		Sox9tm1.2Ksec/Sox9+ involves: 129S/SvEv * C57BL/6 * FVB/N MGI:7451325


Genotype
MGI:7451323
hm1
Allelic
Composition		 Sox9tm1.2Ksec/Sox9tm1.2Ksec
Genetic
Background		 involves: 129S/SvEv * C57BL/6 * FVB/N
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Sox9tm1.2Ksec mutation (0 available); any Sox9 mutation (33 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging




Genotype
MGI:7451325
ht2
Allelic
Composition		 Sox9tm1.2Ksec/Sox9+
Genetic
Background		 involves: 129S/SvEv * C57BL/6 * FVB/N
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Sox9tm1.2Ksec mutation (0 available); any Sox9 mutation (33 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
behavior/neurological

hearing/vestibular/ear
abnormal endolymphatic duct morphology ( J:332093 )
• reduced proportions of mitochondrial-rich and ribosomal-rich mature cells and concomitant increase immature cells in endolymphatic sac in E14.5 embryos

limbs/digits/tail

mortality/aging
perinatal lethality ( J:332093 )
• only ~10% of mice survive

skeleton

Mouse Models of Human Disease
 DO ID OMIM ID(s) Ref(s)
campomelic dysplasia DOID:0050463 OMIM:114290
 J:332093




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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
10/29/2024
MGI 6.24 		The Jackson Laboratory