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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID
Fyco1tm1.2Arte
targeted mutation 1.2, TaconicArtemis
MGI:7451139
Summary 2 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
Fyco1tm1.2Arte/Fyco1tm1.2Arte involves: C57BL/6J * C57BL/6N * C57BL/6NTac * FVB/N MGI:7531464
cx2
Fyco1tm1.2Arte/Fyco1tm1.2Arte
Tg(CAG-RFP/EGFP/Map1lc3b)1Hill/0
involves: C57BL/6J * C57BL/6N * C57BL/6NTac * FVB/N MGI:7531476


Genotype
MGI:7531464
hm1
Allelic
Composition
Fyco1tm1.2Arte/Fyco1tm1.2Arte
Genetic
Background
involves: C57BL/6J * C57BL/6N * C57BL/6NTac * FVB/N
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Fyco1tm1.2Arte mutation (0 available); any Fyco1 mutation (44 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
vision/eye
• at P60, lens epithelial cells show extensive vacuolization
• at P60, lens fiber cells are large and display irregular shapes
• at P0, P7, and P14, differentiating lens fiber cells show abnormal retention of cellular organelles, including endoplasmic reticulum (ER), mitochondria, and Golgi apparatus (GA), suggesting impaired organelle removal
• mice show initial signs of lens opacities at 4 weeks that develop into mild cataracts at ~8 weeks of age
• mice develop mature bilateral cataracts by 16 weeks of age; extent of lens opacities is variable among mice

cellular
• at P14, lenses show an increased Golgi apparatus mass relative to age-matched wild-type lenses
• at P0, P7, P14 and P21, lenses show an increased ER mass relative to age-matched wild-type lenses
• at P0, lenses show alterations in many autophagy-associated genes, proteins and lipids, including a 1.48-fold increase in the level of SQSTM1/p62 and a modest accumulation of phosphatidylethanolamine (PE) phospholipids, suggesting impaired autophagy

homeostasis/metabolism
• at P0, lenses show alterations in many autophagy-associated genes, proteins and lipids, including a 1.48-fold increase in the level of SQSTM1/p62 and a modest accumulation of phosphatidylethanolamine (PE) phospholipids, suggesting impaired autophagy
• at P0, lenses show a modest accumulation of phosphatidylethanolamine (PE) phospholipids




Genotype
MGI:7531476
cx2
Allelic
Composition
Fyco1tm1.2Arte/Fyco1tm1.2Arte
Tg(CAG-RFP/EGFP/Map1lc3b)1Hill/0
Genetic
Background
involves: C57BL/6J * C57BL/6N * C57BL/6NTac * FVB/N
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Fyco1tm1.2Arte mutation (0 available); any Fyco1 mutation (44 available)
Tg(CAG-RFP/EGFP/Map1lc3b)1Hill mutation (1 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
cellular
• multiphoton laser scanning microscopy showed a 1.3- and 1.6-fold higher GFP intensity in the whole lens and the anterior lens including lens epithelium, respectively, indicating a reduced autophagic flux in mouse lenses

homeostasis/metabolism
• multiphoton laser scanning microscopy showed a 1.3- and 1.6-fold higher GFP intensity in the whole lens and the anterior lens including lens epithelium, respectively, indicating a reduced autophagic flux in mouse lenses





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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
11/12/2024
MGI 6.24
The Jackson Laboratory