Phenotypes associated with this allele

• Allele Symbol: Atl1^tm1.2Cbla
• Allele Name: targeted mutation 1.2, Craig Blackstone
• Allele ID: MGI:7463986
• Summary: 2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Atl1^tm1.2Cbla/Atl1^tm1.2Cbla	B6(FVB)-Atl1^tm1.2Cbla	MGI:7464772
cx2	Atl1^tm1.2Cbla/Atl1^tm1.2Cbla Reep1^Gt(OST398247)Tigm/Reep1^Gt(OST398247)Tigm	B6.Cg-Reep1^Gt(OST398247)Tigm Atl1^tm1.2Cbla	MGI:7464793

Genotype
MGI:7464772

hm1

• Allelic Composition: Atl1^tm1.2Cbla/Atl1^tm1.2Cbla
• Genetic Background: B6(FVB)-Atl1^tm1.2Cbla

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

behavior/neurological

abnormal motor capabilities/coordination/movement ( J:334532 )

• mice show mild behavioral phenotypes from ages 4-24 weeks

digestive/alimentary system

abnormal salivary gland duct morphology ( J:334532 )

• mice exhibit hypogranularity of the ducts of the mandibular salivary gland

endocrine/exocrine glands

abnormal salivary gland duct morphology ( J:334532 )

• mice exhibit hypogranularity of the ducts of the mandibular salivary gland

nervous system

abnormal myelin sheath morphology ( J:334532 )

• mice show occasional small to numerous swollen myelin sheaths

Genotype
MGI:7464793

cx2

• Allelic Composition: Atl1^tm1.2Cbla/Atl1^tm1.2Cbla; Reep1^{Gt(OST398247)Tigm}/Reep1^{Gt(OST398247)Tigm}
• Genetic Background: B6.Cg-Reep1^{Gt(OST398247)Tigm} Atl1^tm1.2Cbla

cardiovascular system

abnormal pulmonary artery morphology ( J:334532 )

• 5 of 6 mice exhibit pulmonary arteriole hyperplasia; varies from being mild and affecting a few vessels, to being moderate and affecting multiple vessels

• the majority of pulmonary vessels have inflammatory cells surrounding them

cellular

abnormal endoplasmic reticulum morphology ( J:334532 )

• mice show transverse endoplasmic reticulum (ER) expansion in myelinated corticospinal axons

endocrine/exocrine glands

abnormal Harderian gland morphology ( J:334532 )

• 3 of 11 mice show metaplastic change to the harderian gland

growth/size/body

decreased body weight ( J:334532 )

hearing/vestibular/ear

increased susceptibility to otitis media ( J:334532 )

• 4 of 6 mice exhibit otitis media

immune system

increased susceptibility to otitis media ( J:334532 )

• 4 of 6 mice exhibit otitis media

nervous system

abnormal corticospinal tract morphology ( J:334532 )

• mice show transverse ER expansion in myelinated corticospinal axons