Phenotypes associated with this allele

• Allele Symbol: Gins3^em1Pcamp
• Allele Name: endonuclease-mediated mutation 1, Philippe Campeau
• Allele ID: MGI:7464047
• Summary: 2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Gins3^em1Pcamp/Gins3^em1Pcamp	C57BL/6N-Gins3^em1Pcamp	MGI:7464087
ht2	Gins3^em1Pcamp/Gins3^+	C57BL/6N-Gins3^em1Pcamp	MGI:7464090

Genotype
MGI:7464087

hm1

• Allelic Composition: Gins3^em1Pcamp/Gins3^em1Pcamp
• Genetic Background: C57BL/6N-Gins3^em1Pcamp

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

lethality during fetal growth through weaning, complete penetrance ( J:331868 )

• most embryos die and are resorbed during embryonic development

• no pups found at weaning

embryo

decreased embryo weight ( J:331868 )

• reduced weight from age E12.5

growth/size/body

decreased embryo weight ( J:331868 )

• reduced weight from age E12.5

fetal growth retardation ( J:331868 )

• reduced weight from age E12.5

cellular

early cellular replicative senescence ( J:331868 )

• in cultured MEFs

decreased DNA replication ( J:331868 )

• in cultured MEFs

• MEFs cells accumulate in S phase

homeostasis/metabolism

decreased DNA replication ( J:331868 )

• in cultured MEFs

• MEFs cells accumulate in S phase

Genotype
MGI:7464090

ht2

• Allelic Composition: Gins3^em1Pcamp/Gins3⁺
• Genetic Background: C57BL/6N-Gins3^em1Pcamp

embryo

embryo phenotype ( J:331868 )

N • viable

mortality/aging

mortality/aging ( J:331868 )

N • viable