Phenotypes associated with this allele

• Allele Symbol: Dnm2^tm4.1Ics
• Allele Name: targeted mutation 4.1, Mouse Clinical Institute
• Allele ID: MGI:7464883
• Summary: 2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Dnm2^tm4.1Ics/Dnm2^tm4.1Ics	involves: C57BL/6N	MGI:7464906
ht2	Dnm2^tm4.1Ics/Dnm2^+	involves: C57BL/6N	MGI:7464907

Genotype
MGI:7464906

hm1

• Allelic Composition: Dnm2^tm4.1Ics/Dnm2^tm4.1Ics
• Genetic Background: involves: C57BL/6N

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

perinatal lethality, complete penetrance ( J:329580 )

• all embryos or pups die before age P2

muscle

abnormal skeletal muscle fiber morphology ( J:329580 )

• abnormal nuclei shape and central chains of nuclei in E18.5 embryos

• normal size and general organization

Genotype
MGI:7464907

ht2

• Allelic Composition: Dnm2^tm4.1Ics/Dnm2⁺
• Genetic Background: involves: C57BL/6N

muscle

abnormal skeletal muscle fiber morphology ( J:329580 )

• rounder at age 8 weeks

decreased skeletal muscle fiber size ( J:329580 )

• hypotrophy at age 8 weeks

mortality/aging

preweaning lethality, incomplete penetrance ( J:329580 )

• many embryos or pups die between E18.5 and P10

• animals that survive past P10 live till at least age 18 months

growth/size/body

decreased body weight ( J:329580 )

• from age P2 to 8 weeks

behavior/neurological

decreased food intake ( J:329580 )

• less milk in stomach at age P2

decreased grip strength ( J:329580 )

• severe decrease in hanging ability from age 3 to 8 weeks

homeostasis/metabolism

homeostasis/metabolism phenotype ( J:329580 )

N • normal blood glucose levels

cellular

abnormal mitochondrial crista morphology ( J:329580 )

• most crista absent in some muscle fiber mitochondria

abnormal mitochondrial shape ( J:329580 )

• some muscle fiber mitochondria rounded

increased mitochondrial size ( J:329580 )

• some muscle fiber mitochondria enlarged