Phenotypes associated with this allele

• Allele Symbol: Ncf1^em1Nansh
• Allele Name: endonuclease-mediated mutation 1, Nan Shen
• Allele ID: MGI:7464912
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Ncf1^em1Nansh/Ncf1^em1Nansh	involves: C57BL/6J	MGI:7464942

Genotype
MGI:7464942

hm1

• Allelic Composition: Ncf1^em1Nansh/Ncf1^em1Nansh
• Genetic Background: involves: C57BL/6J

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

hematopoietic system

hematopoietic system phenotype ( J:329553 )

N • normal immune cell ratios

immune system

immune system phenotype ( J:329553 )

N • normal immune cell ratios

mortality/aging

increased susceptibility to induced morbidity/mortality ( J:329553 )

• lower survival rate after systemic lupus erythematosus (SLE) induction with imiquimod (IMQ)

• more severe splenomegaly and higher splenic weight after SLE induction with IMQ

• larger glomeruli, greater deposition of IgG antibodies and more immune cell infiltration in kidney after SLE induction with IMQ

• higher levels of proteinuria and autoantibodies in serum after SLE induction with IMQ

• greater reduction of plasmacytoid dendritic cell (pDC) levels after SLE induction with IMQ

• greater decline in proportion of marginal zone B cells (MZBs) and transitional 2 B cells (T2Bs) after SLE induction with IMQ

• greater increase in transitional 1 B cell (T1B) and age-related B cell (ABC) levels after SLE induction with IMQ